中东呼吸综合征冠状病毒感染  

An overview of the novel coronavirus MERS-CoV

作　　者：段昭君[1] 谭文杰[2] 鲁凤民[1] 

机构地区：[1]北京大学医学部基础医学院病原生物学系和感染病中心,北京100191 [2]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《中国病毒病杂志》2013年第4期245-249,共5页Chinese Journal of Viral Diseases

基　　金：国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2013ZX10004-101);国家科技部973课题(2011CB504704)

摘　　要：2012年6月,沙特地区1名老人因感染一种新型冠状病毒HCoV-EMC/2012而死亡的事件引起人们对这种新型冠状病毒的关注。截至2013年6月7日,全球共有55例患者确诊感染该病毒,其中31例死亡。本文从事件回顾、临床症状、基因组特征、致病机制、流行病学、实验室诊断以及预防与治疗等方面对此新型冠状病毒作一简单介绍,以加强民众意识,做好预防准备,防止类似SARS冠状病毒引起的流行暴发。The epidemic of severe acute respiratory syndrome （SARS） drew much attention for research on human coronaviruses that cause severe lower respiratory tract infection. Very recently, a new disease, the Middle East respiratory syndrome （MERS） reported in September 2012 leads to the finding of a new corona- virus named as MERS-CoV or HCoV-EMC/2012. By June 7, 2013, 31 out of 55 patients died of HCoV- EMC/2012 infection. In this review, we summarize the identification of this novel eoronavirus and compare the clinical symptoms, genome characterization, pathogen, epidemiology, diagnostic approaches, prevention and treatment of MERS and SARS. In addition to some similar symptoms to SARS, HCoV-EMC/2012 can lead to renal failures. Genome sequencing proved HCoV-EMC/2012 a novel species in the genus Betacorona- virus. On May 23, 2013, the World Health Organization （WHO） officially defined the name of this novel coronavirus as MERS^CoV. Although MERS-CoV infections are not so prevalent, the unclear pathogenic mechanisms and limited diagnostic approaches may lead to potential hazards and therefore, more attention should be taken in the study of this virus infection.

关 键 词：新型冠状病毒 HCoV-EMC 2012 肺炎 SARS 肾衰竭 中东呼吸综合征冠状病毒 

分 类 号：R373.1[医药卫生—病原生物学]