湖南省126例HIV抗体阳性产妇生育新生儿感染状况分析  

Effective prevention of HIV-1 mother-to-child transmission:analysis of 126 HIV positive mothers and the infection status of their newborn children in Hunan,China

作　　者：李向忠[1] 贺健梅[1] 吴让香[2] 曾侯霖[2] 陈曦[1] 

机构地区：[1]湖南省疾病预防控制中心,湖南长沙410005 [2]长沙市妇幼保健院,湖南长沙410001

出　　处：《中国病毒病杂志》2013年第4期290-292,共3页Chinese Journal of Viral Diseases

基　　金：湖南省卫生厅科研计划项目(B2012-116)

摘　　要：目的了解湖南省艾滋病病毒(HIV)母婴传播状况,为制定防治策略提供依据。方法湖南省于2009年启动预防艾滋病母婴传播项目。采用回顾性调查方法,根据国家妇幼卫生综合信息平台中的"预防艾滋病母婴传播管理信息系统"追踪到湖南省2010-2012年在该系统中上报的126例HIV-1抗体阳性孕妇及其所生126例婴幼儿,收集母亲HIV-1抗体检测、抗病毒治疗和分娩与喂养方式等情况,并对婴幼儿进行HIV-1DNA和HIV-1抗体检测,明确其HIV感染状况。结果 126例HIV-1抗体阳性孕妇,共生育HIV-1阳性婴幼儿11例。采用孕妇、婴幼儿抗病毒治疗和剖宫产分娩方式为母婴阻断干预措施者,未发生母婴传播,母婴传播发生率为0(0/46)。未进行任何母婴阻断干预者22例,生育9例HIV-1阳性婴幼儿,母婴传播发生率为40.91%(9/22)。孕妇和婴幼儿未服药的情况下,采用剖宫产分娩方式为母婴阻断干预措施的母婴传播发生率为7.14%(1/14)。结论预防艾滋病母婴传播措施能有效降低艾滋病母婴传播发生水平。Objective To study HIV mother-to-child transmission （MTCT） in Hunan province of China and provide evidence for strategies of prevention. Methods The HIV/AIDS MTCT prevention program in Hunan province was launched in 2009. A total of 126 HIV-1 antibody positive pregnant women and their newborn in- fants were reported in the program during 2010 to 2012. The reported data included the results of mother HIV antibody test, antiviral therapy and the ways of delivery and feeding. The HIV-1 DNA and HIV antibody of the newborn infants were detected. Results Of all lZ6 HIV-1 antibody positive pregnant women, 11 infants were diagnosed of HIV-I infection. The MTCT incidence was 0% （0/46） in the group with antiviral therapy plus cesarean delivery （C-section birth） while the rate was 40.91% （9/22） in the group without interven- tion. The MTCT incidence was 7.14%（1/14） in the group with C-section only but without antiviral thera py. Conclusions The precautionary measures such as antiviral therapy and C-section can effectively prevent mother-to-child transmission of HIV.

关 键 词：HIV 母婴传播 抗病毒治疗 剖宫产 

分 类 号：R446.6[医药卫生—诊断学]