^99Tc^m-替曲膦与^99Tc^m-MIBI门控心肌灌注显像的对比研究  

Comparative study of gated myocardial perfusion imaging using ^99Tc^m-tetrofosmin and ^99Tc^m-sestamibi

作　　者：王瑞华[1] 阮翘[1] 孙珂[1] 韩星敏[1] 孙秉奇[1] 谢新立[1] 程兵[1] 陈艳林[1] 刘保平[1] 

机构地区：[1]郑州大学第一附属医院核医学科、河南省高等学校临床医学重点学科开放实验室,450052

出　　处：《中华核医学与分子影像杂志》2013年第4期258-262,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的对比^99Tc^m-替曲膦（TF）和^99Tc^m-MIBIG—MPI的左室心肌灌注及左室心功能参数结果，探讨^99Tc^m-TF能否作为临床G-MPI常规显像剂。方法^99Tc^m-标记TF和MIBI并进行放化纯测定。选取2011年12月至2012年5月间既往健康、排除严重心律不齐及临床拟诊为心肌炎、心肌病的112例受试者（研究经医院伦理委员会批准，患者签署知情同意书），采用简单随机抽样法将其随机分成2组，分别行-日法^99Tc^m-TF（47例，运动负荷状态下注射显像剂370MBq，静息状态下注射显像剂740MBq）G．MPI和两El法^99Tc^mMIBI（65例，注射剂量均为555MBq）G—MPI，所有受试者均于1周内行CAG和UCG检查。利用Cedars定量门控SPECT（QGs）软件获得左室心功能参数，包括LVEF、EDV、ESV、峰充盈率（PFR）、峰射血率（PER）及相位标准差（SD）。采用SPSS17．0软件进行疋。检验、两独立样本t检验、配对t检验及直线相关分析。结果^99Tc^m-TF和^99Tc^m-MIBI放化纯分别为（97．5±0．4）％和（99．1±0．2）％。与CAG结果对比，^99Tc^m-MIBI心肌灌注结果符合率为90．5％（57／63），^99Tc^m-TF为88．9％（40／45），两者差异无统计学意义（X^2=0．389，P〉0．05）。^99Tc^m-TF和^99Tc^m-MIBIG—MPI获得的左室心功能参数差异也无统计学意义[LVEF：（62．60±13．56）％与（60．52±7．08）％，t=0．940；EDV：（103．31±17．29）ml与（98．52＋19．37）ml，t：1．348；ESV：（41．73±12．69）ml与（46．05±10．81）ml。t=0．851：PER：（273±067）EDV／s与（261±1．04）EDV／s，t=n725；PFR：（2．13±0．80）EDV／s与（2．07＋1．09）EDV／s，t=0．339；相位SD：（5．58±4．16）。与（5．97±4．64）。X^2=0．450，均P〉0．05]。两者G．MPI获得的左室心功能参数与UCG结果差异无统计学意义[LVEF：（61．39±10．28）％与（62．13±8．51）％，t=0．991；EDV：（100．50＋18．61）ml与（101．70±1Objective To compare the results of ^99Tc^m-tetrofosmin （TF） and 99Tcm-MIBI G-MPI in evaluating left ventricular myocardial perfusion and other functional parameters. Methods TF and MIBI were both labeled by 99Tern and the radiochemical purities were tested. During December 2011 to May 2012, 112 patients who had examinations of CAG and eehocardiograph in one week after G-MPI were divided into ^99Tc^m-TF group （47 patients） and 99Tcm-MIBI group （65 patients） by simple random sampling. Patients who suffered from severe arrhythmia, clinically suspicious of mycarditis or eardiomyopathy were excluded. The research was approval by the ethics committee, and all patients signed informed consents. One-day ^99Tc^m- TF G-MPI and two-day ^99Tc^m-MIBI G-MPI were performed. The left ventrieular functional parameters were acquired automatically by Cedars quantitative gated SPECT （QGS） software, including LVEF, EDV, ESV, peak filling rate （PFR）, peak ejection rate （PER） and phase standard difference （SD）. The data were analyzed using X^2 test, two-sample t test, paired t test and linear correlation analysis by SPSS 17.0. Results The ra- diochemical purities of ^99Tc^m-TF and ^99Tc^m-MIBI were （97.5±0.4） % and （99.1± 0.2） % respectively. The coincidence rates of ^99Tc^m-TF and ^99Tc^m-MIBI G-MPI with CAG were 88.9% （ 40/45 ） and 90.5% （ 57/63 ）, respectively. There was no significant difference between G-MPI results of the two agents （X^2 = 0.389, P〉 0. 05）. There was also no significant difference between left ventricular functional parameters of the two a- gents （LVEF： （62.60±13.56）% vs （60.5±7.08）%, t=0.940; EDV： （103.3±17.29） ml vs （98.52± 19.37） ml, t=1.348; ESV： （41.73_＋12.69） mlvs （46.05±10.81） ml, t=0.851; PER： （2.73＋0.67） EDV/s vs （2.61±1.04） EDV/s, t=0.725; PFR： （2.13_＋0.80） EDV/s vs （2.07_＋1.09） EDV/s, t=0.339; phase SD： （5.58±4.16）] vs （5.97±4.64）°, t=0.450; all P〉0.05）. There was no s

关 键 词：心肌疾病 体层摄影术 发射型计算机 单光子 锝 替曲膦 MIBI 

分 类 号：R817.4[医药卫生—影像医学与核医学]