826例高甘油三酯血症患者证候要素特征的隐结构模型评价  

Latent Structure Model Evaluation of Syndrome Elements and Features in 826 Hypertriglyceridemia Patients

作　　者：何伟[1,2] 郭树仁[3] 谢雁鸣[4] 刘平兰[3] 田峰[2] 张燕[3] 赵君贤[3] 刘和平[3] 

机构地区：[1]陕西中医学院基础医学院,陕西咸阳712046 [2]中国中医科学院博士后流动站,北京100700 [3]北京北大维信生物科技有限公司,北京100080 [4]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中国中西医结合杂志》2013年第8期1059-1063,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金："重大新药创制"科技重大专项"十一五"计划第一批课题(No.2008ZX09202-007)

摘　　要：目的评价高甘油三酯血症患者的主要中医证候要素特征。方法采用隐结构模型方法,构建826例高甘油三酯血症患者的隐树结构图,采用隐类概率、条件概率、互信息及累积信息覆盖率量化症状/证候数据,以人工判读方法诠释高甘油三酯血症患者的主要证候要素特征。结果以累积信息覆盖率达到95%为主要证候要素的判定标准,826例高甘油三酯血症患者以中、重度症状/证候表现为主(隐类概率分别为35%和60%),其证候要素以气虚、气滞、火热、瘀血、阴虚、阳虚为主,证候要素靶位以心、肝、肾为主。结论基于隐结构模型的证候要素评价方法,可量化各变量(证候要素、中医症状)的关联程度及发生概率。Objective To evaluate main Chinese medical syndrome elements and features of hy- pertriglyceridemia patients. Methods Using latent structure model （LSM） method, the latent structure diagram of 826 hypertriglyceridemia patients were established. Hypertriglyceridemia syndrome elements and features were interpreted by using latent probability ,conditional probability, mutual information, and cumulative information coverage to quantify symptoms/syndromes data ,as well as using manual interpre- tation methods. Results The accumulative information coverage rate reaching 95% was taken as the judgment standard for major syndrome elements. In the 826 hypertriglyceridemia patients, moderate and severe symptoms/syndromes （with the latent probability being 35% and 60% respectively） were domi- nant. The syndrome elements mainly included qi deficiency,qi stagnation,fire heat,stasis blood,yin defi- ciency,and yang deficiency. The main targets were dominated in Xin, Gan, and Shen. Conclusion LSM based syndrome element evaluation method could quantify the association degree of each variable （syn- drome element; Chinese medical symptoms） and the occurrence probability.

关 键 词：隐结构模型 证候要素 高甘油三酯血症 

分 类 号：R259[医药卫生—中西医结合]