可溶性酪氨酸激酶受体1/胎盘生长因子比值在子痫前期诊断中的价值  

Diagnostic Value of Soluble Tyrosine Kinase Receptor 1/Placental Growth Factor in Preeclampsia

作　　者：朱丽丹[1] 江明华[1] 张小芬[1] 李仁良[2] 夏淑琦[2] 

机构地区：[1]温州医学院附属第二医院,浙江温州325000 [2]浙江省温州市第三人民医院,浙江温州325000

出　　处：《实用妇产科杂志》2013年第8期603-606,共4页Journal of Practical Obstetrics and Gynecology

基　　金：温州市科技局资助项目(编号:Y20070099)

摘　　要：目的:探讨血清、尿液可溶性酪氨酸激酶受体1/胎盘生长因子(sFlt-1/PLGF)比值在子痫前期的诊断价值。方法:检测及比较分析40例正常孕妇、38例轻度子痫前期与32例重度子痫前期孕妇血清及尿液中PLGF、sFlt-1及sFlt-1/PLGF比值的变化,将尿液PLGF、sFlt-1分别与血清PLGF、sFlt-1进行Person相关分析,并用ROC曲线分析血清、尿液中sFlt-1/PLGF比值对子痫前期的诊断价值。结果:轻度子痫前期组血清、尿液sFlt-1/PLGF比值高于正常对照组,重度子痫前期组sFlt-1/PLGF比值高于轻度子痫前期组,各组之间的差异均有统计学意义(均P<0.01);尿液PLGF、sFlt-1分别与血清PLGF、sFlt-1具有正相关性(r=0.692,r=0.784,均P<0.05);血清、尿液sFlt-1/PLGF比值对轻度子痫前期的ROC曲线下面积(AUC)分别为0.921、0.935,血清、尿液sFlt-1/PLGF比值对重度子痫前期的ROC的AUC分别为0.959、0.972。血清中sFlt-1/PLGF比值的AUC与尿液中sFlt-1/PLGF比值的AUC相比差异均无统计学意义(均P>0.05)。结论:血清、尿液sFlt-1/PLGF比值在子痫前期患者中均有明显的升高,其为子痫前期的诊断提供了一个较理想的实验室指标,在临床中可以用尿液sFlt-1/PLGF比值替代血液sFlt-1/PLGF比值。Objective：To explore the diagnostic value of serum and urine sFIt -1/PLGF in preeclampsia. Methods： Enzyme linked immunoso_rbentassay method was used to detect the levels of PLGF,sFIt-1 in ser- um and urine of 40 normal pregnant women （control group）,38 patients with mild preeclampsia （mild pre- eclampsia group） and 32 patients with severe preeclampsia （ severe preeclampsia group）. The level of sFIt-1, PLGF and ratio of sFIt-1/PLGF were compared among the three groups. The correlations between lev- els of PLGF,sFIt-1 in serum with levels of PLGF,sFIt-1 in urine were analyzed,The diagnosis value of the ra- tio of sFIt-1/PLGF in serum and urine for preeclampsia was also analyzed. Results：Ratios of sFIt - 1 / PLGF in serum and urine in mild preeclampsia group were significantly higher than those in control group, ratios of sFIt - 1 ! PLGF in serum and urine in severe preeclampsia group were significantly higher than those in mild preeclampsia group（ P 〈0. 01 ）. There were positive correlations between the levels of PLGF,sFIt-1 in urine with those in serum （r=0. 692 and 0. 784, respectively, both P 〈 0.05） ;The area under the curve （AUC） of the ROC curve of sFIt-I/PLGF ratio in serum and urine for mild preeclampsia diagnosis was 0. 921 and 0. 935 respectively;The AUC of the ROC curve of sFIt-1/PLGF ratio in serum and urine for severe pre- eclampsia diagnosis was 0. 959 and 0. 972 respectively. There was no significant difference on AUC of sFIt-1/PLGF ratio between in serum and that in urine. Conclusions：The ratios of sFIt-I/PLGF in patients with preeclampsia in serum and urine were significantly elevated,which maybe an ideal index for the diagno- sis of preeclampsia. The ratio of sFI-1/PLGF in urine can be used to replace that in serum in the diagnosis of preeclampsia.

关 键 词：子痫前期 胎盘生长因子 可溶性酪酸激酶受体1 

分 类 号：R714.244[医药卫生—妇产科学]