交替性霍纳氏综合征患者的脑部功能连接变化:附1例报告  

Alterations of brain functional connectivity in a patient with alternating Horner's syndrome:a functional magnetic resonance imaging study

作　　者：陈志晔[1] 范寅泰[2] 李金锋[1] 马林[1] 

机构地区：[1]解放军总医院放射科,北京100853 [2]航天中心医院,北京100049

出　　处：《南方医科大学学报》2013年第8期1177-1180,共4页Journal of Southern Medical University

基　　金：解放军总医院博士创新基金(10BCZ08)

摘　　要：目的探讨交替性霍纳氏综合征(AHS)患者脑部度中心性功能连通性变化。方法对1例AHS患者及8名健康受试者进行脑部结构像及静息态脑功能成像扫描。采用度中心性(DC)方法评价AHS患者脑部静息态默认网络结点的中心性度量变化。统计学采用单样本t检验及双样本t检验,采用假阳性率(FDR)校正,P<0.05有统计学意义。结果 AHS患者左眼发病时DC主要为双侧额中回前部及额盖和岛盖,高于全脑均值的脑区主要为双侧枕叶、颞叶及扣带回,低于正常被试的脑区主要位于左侧颞下回、中央后回,右侧颞上回,枕外侧回及双侧旁中央小叶。右眼发病时DC主要为双侧额上回及额中回前部、顶叶、中扣带回及枕内侧回,高于全脑均值的脑区主要位于双侧枕叶、颞叶及扣带回及双侧额叶眶回、直回,低于正常被试的脑区主要位于左侧缘上回、右侧枕外侧回、旁中央小叶及双侧颞上回。结论 AHS患者脑部改变可表现为多个脑区度中心性功能连接减低。Objective To evaluate the alternations of degree centrality(DC) in the brain of a patient with alternating Horner's syndrome(AHS).Methods Conventional magnetic resonance imaging(MRI),3D structure reconstruction and resting-state functional MRI were performed in a patient with AHS and 8 healthy adults.The DC of brain functional connectivity was calculated and statistically analyzed to evaluate the changes in the nodes in the brain default network of the patient.Results In the AHS patient,the DC at onset of left eye involvement was located mainly in the bilateral anterior middle frontal gyri,frontal operculum and opercula insulae;the brain regions with a DC greater than the mean DC of the whole brain were found mainly in the bilateral occipital lobes,temporal lobes and cingulate gyri,and the brain regions with a significantly decreased DC included mainly the left inferior temporal gyrus,postcentral gyrus,right superior temporal gyrus,lateral occipital gyri and bilateral paracentral lobules(P<0.05).At the onset of right eye involvement,the DC was mainly located in the anterior part of the bilateral superior and middle frontal gyri,parietal lobes,middle cingulate gyri and medial occipital gyri;the brain regions with a DC greater than the mean DC of the whole brain included the bilateral occipital lobers,temporal lobes,cigulate,orbital gyri and gyrus rectus,and the brain regions with a significantly decreased DC included the left supramarginal gyrus,right lateral occipital gyrus,paracentral lobule and bilateral superior temporal gyrus.Conclusion The AHS patient exhibited a decreased DC of functional connectivity in multiple brain regions.

关 键 词：交替性霍纳氏综合征 脑 功能磁共振成像 功能连接 静息态功能MRI 

分 类 号：R445.2[医药卫生—影像医学与核医学]