HPV DNA检测(HC2)用于宫颈癌筛查价值的Meta分析  

Efficacy of hybrid capture 2 HPV DNA testing on the screening of cervical cancer:a Meta-analysis

作　　者：李杨[1,2] 尚玉敏[2] 杨阳[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市天和医院妇产科,天津300050

出　　处：《现代妇产科进展》2013年第7期561-564,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨2代杂交捕获法(HC2)检测HPV DNA在宫颈癌筛查中的应用价值。方法:计算机检索PubMed、Embase、Central、CNKI、CBMDisc、万方数据库等。纳入公开发表的有关HC2检测HPV DNA用于筛查宫颈癌的诊断试验,质量评价后,应用STATA11.0和Meta-disc1.4软件进行Meta分析,评价HC2筛查宫颈癌的敏感性、特异性和ROC曲线下面积(AUC)。结果:最终纳入12篇文献,共计12 492例。Meta分析结果显示,HC2检测HPV DNA筛查宫颈癌的敏感性和特异性分别为83%(95%CI为82%～85%)和88%(95%CI为87%～89%);AUC为0.91(95%CI为0.88～0.93)。结论:HC2检测HPV DNA筛查宫颈癌的敏感性和特异性均较高,可作为临床大规模宫颈癌筛查的有效方法。Objective： To evaluate the screening value of hybrid capture 2 （HC2） HPV DNA testing for cervical cancer by meta-analysis. Methods： By searching PubMed, Central （ the Cochrane central register of controlled trials）, Embase, CBM, CNKI and WANFANG et al. All studies about HPV DNA test using HC2 for cervical cancer screening were retrieved from the data bases. The quality of included studies was evaluated by QUADAS items. The sensitivity, specificity and systematic receiver operating characteristic curves （SROC） were calculated to assess the screening value of individual diagnostic test. The data was analyzed by using statistic software Meta-Discl. 4 and STATA11.0. Results ：Twelve cross-sectional studies that included a total of 12492 participants were analyzed in the current meta-analysis. The pooled values of sen- sitivity,specificity were 83% （95% CI 82% -85% ） and 88% （95% CI 87% - 89% ） respec- tively. The area under SROC curve （ AUC ） of HPV DNA （ HC2 ） array for cervical cancer screening was 0, 91 （95% CI O. 88 -0.93 ）. Conclusion ：HPV DNA test using HC2 has relative high sensitivity and specificity in screening of cervical cancer, which can be used as an useful method for cervical cancer screening.

关 键 词：宫颈癌 杂交捕获法 筛查 META分析 

分 类 号：R737.33[医药卫生—肿瘤]