声触诊组织量化技术无创动态评估兔耳增生性瘢痕硬度  

Virtual touch tissue quantification in noninvasive assessment of hypertrophic scar stiffness of rabbit ears

作　　者：游玉芳[1] 王志刚[1,2] 郑元义[1,2] 张花[1] 宋卫香[1] 

机构地区：[1]重庆医科大学超声影像学研究所,重庆400010 [2]重庆医科大学附属第二医院超声科,重庆400010

出　　处：《中国医学影像技术》2013年第8期1237-1242,共6页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金重点项目(81130025);国家自然科学基金青年项目(30900371);国家自然科学基金面上项目(81071158)

摘　　要：探讨声触诊组织量化(VTQ)技术无创评估兔耳增生性瘢痕(HS)形成过程中的硬度变化。方法运用VTQ技术在兔耳HS模型形成过程的不同时间点(术前1天,术后第1、3、5、7、11、16、20、28、36、45、60、90、120天)测量其剪切波速度(SWV),比较相邻时间点的SWV值,同时测量二维图灰阶值,对HS剪切波速度值(HSSWV)及灰阶值进行对比分析。结果 HS形成过程中SWV值比较:除术前1天与术后第1天(P=0.099)、术后第60天与术后第90天(P=0.053)差异无统计学意义外,其余相邻时间点差异均有统计学意义(P均<0.05)。兔耳HS形成过程中,HSSWV值与灰阶值呈正相关(r=0.568,P<0.001);而在兔耳HS增生期(术后11～45天),HSSWV值与灰阶值高度相关(r=0.813,P<0.001)。结论应用VTQ技术测得的HSSWV值在量化评估HS硬度改变方面有重要应用价值。Objective To noninvasively assess the stiffness changes during the process of rabbit ear hypertrophic scar （HS） with virtual touch tissue quantification （VTQ） technique. Methods HS shear wave velocity （SWV） was measured by using VTQ during the day before surgery and the 1st, 3rd, 5th, 7th, 11th, 16th, 20th, 28th, 36th, 45th, 60th, 90th, 120th day postoperatively, respectively. The values of SWV were compared between the two adjacent times. B-mode grey scale was also tested and analyzed with SWV. Results Except the 1st preoperative day vs. the 1st postoperative day （P=0.099）, the 60th postoperative day vs. the 90th postoperative day （P=0.053）, the differences were all statistical between each other two time points （all P〈0.05）. Positive correlation （r=0.568, P〈0.001） was found between HSSWV and B-mode grey scale on the whole process of rabbit ear HS. Significant, direct, linear correlation （r=0.813, P〈0.001） was found between HSSWV and B-mode grey scale during the 11th day to the 45th day postoperatively. Conclusion VTQ technique has important application value in the noninvasive assessment of HS stiffness.

关 键 词：剪切波速度 声触诊组织量化 增生性瘢痕 无创 

分 类 号：R619.6[医药卫生—外科学]