鸡抗病毒免疫相关的TLR信号途径研究进展  

Process on Antiviral Immunity Associated Chicken Toll-like Receptor Signaling Pathway

作　　者：李海超[1,2] 韩凌霞[1] 

机构地区：[1]中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室/实验动物中心,黑龙江哈尔滨150001 [2]东北农业大学,黑龙江哈尔滨150030

出　　处：《动物医学进展》2013年第8期93-96,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31101800)

摘　　要：Toll样受体(TLR)是进化保守的模式识别受体家族之一,在启动和调节宿主对病原体的免疫应答中起重要的作用。已经报道在鸡体中发现了10种TLR,与哺乳动物的同源物相比,在进化中高度保守,能识别病原体中保守的组成成分,其中TLR3、TLR7和TLR 21主要识别核酸配体,在细胞内体上分布,在抗病毒免疫中尤为重要。论文主要对鸡TLR3、7和21在抗病毒免疫中的作用及信号途径进行综述。Toll-like receptor （TLR） is evolutionarily conserved family of pattern recognition receptors （PRRs） ,and play an important role in the activation and regulation of the host response to pathogens. 10 TLRs have been founded in chicken. TLRs are highly conserved in evolution and recognition of the patho- gen conservative components. TLR recognition of pathogen associated molecular patterns（PAMPs） not on- ly plays an important role in the innate immunity, and also is able to active the acquired immunity. Chicken TLR3,7 and 21 in the antiviral immune signaling pathways were reviewed.

关 键 词：TOLL样受体 抗病毒免疫 信号途径 鸡 

分 类 号：Q527.5[生物学—生物化学]