宫颈注射天花粉蛋白治疗宫颈妊娠疗效观察  

Clinical observation on the effect of trichosanthin intracervical injection on cervical pregnancy

作　　者：张宣东[1] 张华[1] 曾敏华[1] 

机构地区：[1]解放军第四一一医院妇产科,上海200081

出　　处：《海军医学杂志》2013年第4期229-231,共3页Journal of Navy Medicine

摘　　要：目的探讨宫颈注射天花粉蛋白治疗宫颈妊娠的疗效。方法 3例确诊为宫颈妊娠患者,肌肉注射地塞米松5 mg防过敏反应,再取皮试液做皮内试验,观察无不良反应后,于宫颈3点、9点处各注射天花粉蛋白1.2 mg,并间隔3～5 d复查血人绒毛膜促性腺激素β亚单位(β-hCG),每周复查B超及血常规。结果 3例血β-hCG均下降至100 U/ml以下,B超提示宫颈包块或孕囊周围血流消失,行清宫术,术中、术后出血少于1000 ml,均治愈出院,保全了子宫,无明显不良反应。平均住院22 d。结论宫颈注射天花粉蛋白治疗宫颈妊娠效果明显。Objective To investigate therapeutic effects of trichosanthin intracervical injection on cervical pregnancy. Methods Three patients, who were diagnosed as cervical pregnancy, received 5 mg dexamethason （DXM） for protection of allergic reaction. Intracutaneous test was made to assure that vital signs were all normal. With absence of adverse reactions, trichosanthin with a dosage of 1.2 mg was injected respectively at the sites of 3 and 9 o＇clock of uterine neck. Serum human chorionic gonadotropin-fl cer- vical pregnancy（fl-hCG）were examined every 3 to 5 days. Ultranonography and blood routine were also made every week. Results fl- hCG of the 3 patients all decreased to a level below 100 U/ml. Uhranonography indicated that blood flow around the pregnant sac was not visible. There were no significant adverse reactions in the course of treatment and hysterectomy was avoided. All the 3 patients were cured and discharged from the hospital and the duration of their stay at the hospital was on the average 22 days. Conclusion Trichosan- thin intracervical injection seemed to produce good effects on cervical pregnancy.

关 键 词：宫颈妊娠 天花粉蛋白 宫颈注射 

分 类 号：R714.22[医药卫生—妇产科学]