血浆(1-3)-β-D-葡聚糖对侵袭性真菌感染诊断价值的荟萃分析  

Plasma(1-3)-β-D-Glucan Assayin the Diagnosis of Invasive Fungal Infections:A Meta-analysis

作　　者：黄晓春[1] 陈岩[1] 沈茜[1] 秦阳华[1] 

机构地区：[1]第二军医大学附属长海医院实验诊断科,上海200433

出　　处：《标记免疫分析与临床》2013年第4期239-242,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的采用荟萃分析评价血浆(1,3)-β-D-葡聚糖检测对侵袭性真菌感染的诊断价值。方法采用STATA11软件分析纳入研究项目血浆(1,3)-β-D-葡聚糖浓度诊断侵袭性真菌感染总的灵敏度、特异度,阳性似然比和阴性似然比。结果纳入的31组研究数据分析显示总的灵敏度,特异度,阳性似然比和阴性似然比分别为0.79(95%CI,0.73～0.85),0.86(95%CI,0.80～0.90),5.64(95%CI,3.818～8.352),和0.242(95%CI,0.179～0.326)。结论荟萃分析显示血浆(1,3)-β-D-葡聚糖检测对于诊断IFI有较高的临床价值。Objective To explore the overall accuracy of plasma （1-3 ）-β-D-glucan assay for diagnosing of invasive fungal infections （IFI） with a meta： analysis. Methods The sensitivity, specificity, and positive and negative likelihood ratios of （1-3）-β-D-glucan in the diagnosis of IFI were pooled using a bivariate meta-analysis with STATA 11. Results Thirty- one studies were included for the analysis （ proven, probable, and possible IFI vs no IFI）. The pooled sensitivity, specificity, PLR and NLR were 0.79 （95% CI, 0. 73-0. 85 ） , 0.86 （95% CI, 0. 80-0. 90） , 5.64 （95% CI, 3. 818-8. 352）, and 0. 242 （95% CI, 0. 179-0.326）, respectively. Conclusion Plasma （1-3）-β-D-glucan assay is clinically useful for diagnosing IFI in at-risk patients.

关 键 词：葡聚糖 侵袭性真菌感染 荟萃分析 

分 类 号：R519[医药卫生—内科学]