超声辐射下一锅法合成2-乙酰氨基噻唑衍生物  

One-Pot Synthesis of 2-Acetamide-thiazole Derivatives under Ultrasonic Irradiation

作　　者：崔朋雷[1] 张冬暖[1] 刘卉闵[1] 张英群[1] 

机构地区：[1]河北农业大学理学院,河北保定071001

出　　处：《广州化工》2013年第15期64-65,139,共3页GuangZhou Chemical Industry

基　　金：保定市科技局科技支撑计划资助项目(No:12ZF077)

摘　　要：以α-溴代酮、硫脲和乙酸酐为原料,超声辐射下一锅法合成了一系列2-乙酰氨基噻唑衍生物,最佳条件是:以乙醇为溶剂,辐射功率为300 W,n(α-溴代芳基酮)∶n(硫脲)=1∶1,反应温度为30～35℃。该方法反应时间短、操作简单、后处理方便。目标化合物的结构通过1H NMR,IR和元素分析进行了表征。An efficient one - pot method was used to prepare a series of 2 - acetamide, thiazole derivatives from α - bromoketone, thiourea and acetic anhydride under ultrasonic irradiation. The optimum conditioris were that ethanol as solvent, microwave power was 300 W, n （α -brominated aryl ketone） ： n （thiourea） = 1 ： 1, and reaction temperature was 30 - 35℃. The reaction procedures had the advantages of easy work up, short time and simple operation. The products were identified by 1H NMR and IR spectra and elemental analysis.

关 键 词：超声辐射 一锅法合成 2-乙酰氨基噻唑衍生物 

分 类 号：O626[理学—有机化学]