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作 者:梁秋发[1] 黄立清[1] 王强[2] 甘春葆[2] 刘岭峰[1]
机构地区:[1]佛山科学技术学院门诊部,广东佛山528000 [2]佛山科学技术学院医学院,广东佛山528000
出 处:《医学临床研究》2013年第7期1249-1251,共3页Journal of Clinical Research
基 金:广东省自然科学基金资助项目(10152800001000030)
摘 要:【目的】研究肿瘤坏死因子a拮抗剂依那西普治疗强直性脊柱炎(AS)的疗效及作用机制。【方法143例活动性AS患者,随机分为治疗组(23例,给予依那西普25mg,皮下注射,2次/周,共6周)和对照组(20例,给予安慰荆治疗)。用流式细胞术分析比较两组治疗前后患者树突状细胞(DC)和调节性T细胞(Treg)水平。酶联免疫吸附试验(ELISA)检测血清中可溶性白细胞介素2(IL-2)受体水平。【结果】治疗组与对照组比较DC和Treg数量升高(P〈0.05),血浆可溶性IL-2受体水平降低(Pd0.05)。【结论】依那西普阻断DC的成熟,从而增强了Treg的水平,并抑制了效应T细胞的功能从而改善病人的临床症状。[ Objective]To explore the action mechanism of etanercept for the treatment of active ankylosing spondylitis(A$). EMethods~ Forty-three active AS patients were randomly divided into treatment group and control group. The treatment group( n =23) received etanercept 25rag by subcutaneous injections twice a week. The control group( n =20) received placebo therapy. Flow cytometry was used to analyze the levels of dendritic cells(DC) and regulatory T cells(Treg) before and after treatment. Enzyme-linked immunosorbent assay(ELISA) was used to detect serum soluble interleukin-2 (IL-2) receptor. [Results]Compared with the control group, DC and Treg level increased ( P 〈0.05) and soluble IL-2 receptor decreased in the treatment group( P 〈0.05). [Conclusion]Etanercept can block the DC maturation, increase the level of regulatory T cell and inhibit the function of responsive T cells so as to improve clinical symptoms of active AS patients.
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