乙肝病毒携带者围产期垂直传播防治策略探讨  

A strategic study on the prevention and treatment of perinatal vertical transmission in hepatitis B virus carriers.

作　　者：吴俭[1] 曾义岚[1] 胡蓉[1] 唐洪玉[2] 

机构地区：[1]成都市传染病医院,610016 [2]成都市妇产科医院

出　　处：《四川医学》2000年第11期947-948,共2页Sichuan Medical Journal

摘　　要：目的　比较乙肝病毒携带 HBe Ag(+ )与 HBe Ag(- )产妇的乳汁、婴儿静脉血乙肝病毒血清标志物(HBVM)阳性率 ,了解其对垂直传播的影响 ,以采取相应的防治措施。方法　把乙肝病毒携带产妇按 HBe Ag(+ )与HBe Ag(- )分为两组各 35例 ,检测两组乳汁、婴儿静脉血及 1岁幼儿 HBVM,进行卡方检验。结果　母亲 HBe Ag(+ )组宫内感染率为 17.1% (6 / 35 ) ,乳汁 HBV- DNA阳性率为 40 % (14/ 35 ) ;而母亲 HBe Ag(- )组宫内感染率及乳汁 HBV-DNA阳性率仅为 2 .9% (1/ 35 )。结论　母亲 HBe Ag(+ )组的宫内感染率和乳汁 HBV- DNA阳性率明显高于 HBe Ag(- )组 ,(P<0 .0 1)。建议在围产期应重点监测 HBe Ag(+ )者 ,而 HBe Ag(- )者可与正常孕妇同样对待和处理。Objective To understand the effect of pregnancy with positive HBV replication on vertical transmission,and to shape up a relavant strategy of prevention and treatment.Mthods A total of 70 lying ins were divided into two groups:the HBeAg(+)group (n=35) versus the HBeAg(-) group(n=35).The two groups hepatitis B viral serum markers of milk,infant and one year old child vein blood were examined and compared.Chi square test was employed in statistical analysis.Results The intrauterine infectious rate and the HBV DNA positive rate of milk in HBeAg(+) group were 17.1%(6/35) and 40%(14/35) respectively.The intrauterine infectious rate and HBV DNA positive rate of milk in HBeAg(-)group were only 2.9%(1/35).Conclusion The intrauterine infectious rate and the HBV DNA positive rate of milk in HBeAg(+)group were significantly higher than those in HBeAg(-) group,( P <0.01).It is suggested that the pregnant women with HBeAg(+)have more risk of intrauterine HBV infection and should be intensively monitored,and the lying ins with HBeAg(+) be treated like normals.

关 键 词：乙肝病毒携带者 围产期 垂直传播 防治策略 

分 类 号：R714.251[医药卫生—妇产科学] R512.62[医药卫生—临床医学]