促红细胞生成素及受体神经保护作用的研究进展  

Review on progress of neuroprotective effect of erythropoietin and erythropoietin receptor

作　　者：赵文博[1] 郝斌 杨涛 曹文东 续慧民 皮兴涛 

机构地区：[1]山西医科大学研究生院,山西太原030001 [2]山西大医院血管外科,山西太原030032

出　　处：《中国当代医药》2013年第23期27-28,共2页China Modern Medicine

摘　　要：促红细胞生成素(EPO)是刺激红细胞造血的生长因子和细胞因子。最近几年,有报道显示EPO在神经系统中有重要的非造血功能,对神经系统的发生、维持、保护和修复有极为关键的作用。大量实验研究显示EPO及其受体在神经系统中有表达,在细胞培养和神经系统紊乱的动物模型中EPO发挥着显著的神经保护作用。本文对EPO的分子机制、神经营养和神经保护特性进行综述。Erythropoietin（EPO） is a hematopoietic growth factor and cytokine which stimulates erythropoiesis.In recent years,EPO has been shown to have important nonhematopoietic functions in the nervous system.Nonerythropoietic actions of EPO include a critical role in the development,maintenance,protection and repair of the nervous system.A wide variety of experimental studies have shown that EPO and its receptor are expressed in the nervous system and EPO exerts remarkable neuroprotection in cell culture and animal models of nervous system disorders.In this review,we summarize the current knowledge on molecular mechanisms,neurotrophic and neuroprotective properties of EPO.

关 键 词：促红细胞生成素 促红细胞生成素受体 神经保护 信号转导 

分 类 号：R34[医药卫生—基础医学]