水杉总黄酮对压力超负荷大鼠左室肥厚的作用  

Effects of Total Flavones of Metasequosia on left Ventricular Hypertrophy Due to Pressure Overload in Rats

作　　者：曾加雄[1] 刘惟莞[1] 石明健[1] 杨晓茹[1] 糜留西[2] 卢云英 郑庆安[2] 王红英[1] 

机构地区：[1]湖北医科大学药理教研室,湖北武汉430071 [2]中国科学院武汉植物研究所,湖北武汉430074

出　　处：《中国中药杂志》2000年第10期622-624,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金资助项目!( 3 9770 0 88)

摘　　要：目的 :研究水杉总黄酮对压力超负荷大鼠左室肥厚的预防和逆转作用。方法 :缩窄腹主动脉建立压力超负荷大鼠心肌肥厚模型 ,分别于术后 1周和 6周给予水杉总黄酮ig ,持续 6周。 结果 :预防和逆转部分 ,水杉总黄酮均能显著降低大鼠HW/BW、LVW /BW、心肌纤维直径和左心室肌Ca2 + 含量 ,而使收缩压 (SBP)仅轻微下降 ,结论 :水杉总黄酮对压力超负荷大鼠左室肥厚有预防和逆转作用 ,其机制可能与钙拮抗作用有关。Objective: To determine the preventive and regressive effects of total flavones of metasequosia (TFM)on left ventricular hypertrophy in rats. Method:Left ventricular hypertrophy was inducedin by partial ligation of abdominal aorta.The rats were given ig TFM(4,40,400 mg·kg -1 ·d -1 )for six weeks.Result:TFM markedly reduced the HW/BW,LVW/BW,myofibril diameter and Ca 2+ content in left ventricles but the systolic blood pressure (SBP)in rats wasn't obviously influenced.Conclusion:TFM can prevent and reverse the left ventricular hypertrophy due to pressure overload in rats. The mechanism may be related to its calcium antagonistic properties. [

关 键 词：压力超负荷 左室肥厚 钙 水杉总黄酮 

分 类 号：R285.5[医药卫生—中药学]