HIV/AIDS免疫异常激活及其与疾病进展的相关性研究  

Correlation study of HIV/AIDS abnormal immune activation and disease progression

作　　者：王阶[1] 吴欣芳[1] 李勇[1] 曾毅[2] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《中国中药杂志》2013年第15期2429-2433,共5页China Journal of Chinese Materia Medica

基　　金：国家"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项(2008ZX10005-004)

摘　　要：目的:分析我国艾滋病患者的免疫异常激活水平及其与CD4+T细胞计数、疾病进展的相关性,探讨免疫异常激活在HIV/AIDS发病中的作用。方法:通过检测287例不同病情的未接受过任何治疗的HIV/AIDS患者外周血CD4+T细胞计数,免疫异常激活标志物及血浆病毒载量,对相关数据进行相关性分析。结果:不同疾病进展阶段的HIV/AIDS患者免疫异常激活水平显著不同,随着疾病进展,免疫异常激活水平显著升高。且外周血CD4+T细胞计数与免疫异常激活标志物呈显著的负相关。结论:感染HIV后诱导的免疫异常激活可能是导致CD4+T细胞计数逐渐降低及疾病进展的机制之一。Objective： To learn the levels of immune function and immune activation of HIV/AIDS patients in China and find the correlation between the immune activation and CD4＋T lymphocyte and disease progression. And discuss the relevance of immune activation with HIV/AIDS pathogenesis. Method： Two hundred and eighty seven cases of HIV/AIDS patients in different disease stages who never accept HAART before and 40 healthy HIV negative donors have been involved in the research. Their immune function and abnormal immune activation markers are detected by flow cytometry counts, and the immune activation markers include CD8＋CD38＋T cells and CD8＋HLA-DR＋T cell.Compare the difference of abnormal immune activation between patients of various disease stages. And by Pearson correlation test analysis, the correlation between the immune activation levels and abnormal CD4＋T lymphocyte count and disease progression will be found. Result： The immune abnormal activation levels were significantly different between patients of different disease stages （P〈0.001）. Correlation analysis showed that there was a significant negative correlation between peripheral blood CD4＋T cell counts and immune activation markers. Conclusion： Immune activation induced by HIV infection may lead to decreased CD4＋T cell count and disease progression.keywords：HIV

关 键 词：HIV AIDS 免疫异常激活 疾病进展 相关性 

分 类 号：R512.91[医药卫生—内科学]