氮杂蒽酮类抗肿瘤化合物的研究新进展  

Recent Progress in Research on Aza-anthrones with Antitumor Activity

作　　者：朱炎[1] 朱雄[2] 周金培[1] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009 [2]中国药科大学医药化工研究所,江苏南京210009

出　　处：《药学进展》2013年第7期305-312,共8页Progress in Pharmaceutical Sciences

摘　　要：氮杂蒽酮类化合物是新型蒽酮类抗肿瘤化合物,与传统蒽酮类药物相比,其心脏毒性降低,故对该类化合物的研发对于提高临床用药安全性具有重要意义。分类综述氮杂蒽酮类化合物抗肿瘤活性及构效关系研究的新进展,为高效低毒的该类抗肿瘤化合物的设计与开发提供参考。Aza-anthrones, a new class of anthrone derivatives with antitumor activity, have reduced car- diotoxic potential compared with traditional anthrone drugs, of which the development is of great significance in improving the safety of clinical medication. The recent progress in research on the antitumor activities and structure-activity relationships of different types of aza-anthrones was reviewed to provide a reference for the design and development of the antitumor compounds with higher activity and lower toxicity.

关 键 词：氮杂蒽酮 抗肿瘤活性 构效关系 心脏毒性 

分 类 号：R979.1[医药卫生—药品] R914.2[医药卫生—药学]