慢性肝炎患者IL-2及其受体与IL-6、T细胞亚群的关系  

CHANGES AND SIGNIFICANCE OF IL-2,sIL-2R,IL-6,T SUBSET IN PATIENTS WITH CHRONIC HEPATOPATHY

作　　者：赵彩彦[1] 冯忠军[2] 张素环[1] 汤慧华[2] 刘金星[1] 

机构地区：[1]河北医科大学第三医院感染科,石家庄050051 [2]河北医科大学第三医院中心实验室

出　　处：《河北医科大学学报》2000年第5期260-262,共3页Journal of Hebei Medical University

摘　　要：目的研究慢性肝炎与肝硬化患者IL 2、sIL 2R、IL 6、T细胞亚群的变化和意义。方法分别采用双抗体夹心ELISA法、ABS ELISA法和红细胞花环实验对 74例慢性病毒性肝炎与肝炎肝硬化进行IL 2、sIL 2R、IL 6和T细胞亚群的测定 ,并与 6 6例健康献血员进行对照。结果慢性肝炎轻度 (CH Ⅰ )IL 2水平高于正常对照(NC)组 ,慢性肝炎中度 (CH Ⅱ )、慢性肝炎重度 (CH Ⅲ )、肝炎肝硬化 (LC)患者血清IL 2水平、CD+ 4/CD+ 8比值明显低于CH Ⅰ和NC组 (P <0 .0 1) ;而IL 6、sIL 2R水平显著高于CH Ⅰ和NC组。在慢性乙型肝炎 ,HBV DNA阳性组的IL 2水平显著低于HBV DNA阴性组。在各组病例 ,IL 2与CD+ 4/CD+ 8比值、IL 6与sIL 2R正相关 ,而IL 6与CD+ 4/CD+ 8比值显著负相关 ,IL 2与sIL 2R、IL 6无相关关系。结论慢性肝炎与肝炎肝硬化患者存在免疫功能紊乱和低下、淋巴因子网络失衡 ,此与其病理生理机制有关 ,为临床上慢性肝病应用IL 2及其诱生剂治疗提供了理论依据。ObjectiveTo study the changes and clinical significance of IL 2,sIL 2R,IL 6 and T cell subsets in patients with chronic hepatitis(CH) and liver cirrhosis(LC).MethodsIL 2,sIL 2R,IL 6 and T cell subsets were detected by double antibody sandwich ELISA,avidin biotin system ELISA,erythrocyte rosette test respectively in 74 patients with chronic hepatitis and liver cirrhosis.ResultsThe IL 2 increased in CH Ⅰ,and decreased in patients with CH Ⅱ,CH Ⅲ and LC than CH Ⅰ and normal controls (P< 0.01 ).However IL 6 and sIL 2R levels in patients with CH Ⅱ,CH Ⅲ and LC were much higher than CH Ⅰ and NC.The levels of IL 2 in patients with chronic hepatitis B of HBV DNA positive were lower than that of HBV DNA negative group.The IL 2 had a positive correlation with CD + 4/CD + 8 ratio;a negative correlation with IL 6 and CD + 4/CD + 8 ratio;but no correlation with IL 2 and IL 6 and sIL 2R in CH and LC.There was a positive correlation between IL 6 and sIL 2R.ConclusionThere is immunology disorder,deficiency of maladjustment of lymphokine network in patients with CH and LC.It may be important in the pathophysiology of CH and LC.This results give the rationales for use of IL 2 treatment on immunology basis in CH Ⅱ,Ⅲ and LC.

关 键 词：慢性肝炎 IL-2 IL-6 T细胞亚群 诊断 

分 类 号：R512.603[医药卫生—内科学]