血管紧张素转化酶基因的插入/缺失多态性与心肌梗死的关系  

Association between the insertion/deletion polymorphism of angiotensin converting enzyme gene and the myocardial infarction

作　　者：田丽红[1] 回皓升[1] 刘彩琼[2] 

机构地区：[1]广东医学院附属医院心内科,湛江524001 [2]湛江广东医学院生化教研室

出　　处：《中国综合临床》2000年第11期807-808,共2页Clinical Medicine of China

摘　　要：目的　探讨国人血管紧张素转化酶 (ACE)基因的插入 /缺失 (I/D)多态性与心肌梗死的关系。方法　应用多聚酶链反应方法检测 ACE基因多态性。结果　心肌梗死患者 ACE基因 DD型频率 (0 .38)及 D等位基因频率 (0 .5 8)均明显高于对照组。结论　国人ACE基因 DD型与心肌梗死有关 ,可能是发生心肌梗死的重要危险因素之一。Objective To investigate the association between the insertion/deletion(I/D) polymorphism of angiotensin converting enzyme (ACE) gene and the myocardial infarction (MI) among Chinese population. Methods Polymerase chain reaction(PCR) was applied to the examination of ACE gene polymorphism. A comparison was performed between 50 patients with MI and another 50 healthy subjects.Results The frequencies of DD genotype (0.38) and D allele (0.58) were both higher among the MI group than that among the control group (0.16 and 0.41 respectively,P<0.05).Conclusion The ACE/DD genotype is associated with MI morbidity,which might be an important risk factor for MI among the Chinese population.

关 键 词：血管紧张素转化酶 基因多态性 心肌梗死 

分 类 号：R542.220.2[医药卫生—心血管疾病]