血清前白蛋白、总胆汁酸和胆碱酯酶联合检测在乙型肝炎进展中的临床价值  

Clinical value of serum pre-albumin,total bile acid and cholinesterase detection in progress of hepatitis B

作　　者：梁影[1] 雷婷[1] 石秀芳[1] 刘雪荣[1] 敖家富[1] 

机构地区：[1]安徽省亳州市人民医院检验科,236803

出　　处：《淮海医药》2013年第5期386-387,共2页Journal of Huaihai Medicine

摘　　要：目的明确血清前白蛋白(PA)、总胆汁酸(TBA)和胆碱酯酶(CHE)在乙型肝炎进展中的临床价值。方法 141例临床确诊的乙型肝炎及进展期患者及42例职工体检的HBsAg阴性的正常人群,均于清晨空腹采集静脉血,采用日立7600-020全自动生化分析仪测定PA、TBA和CHE。结果与对照组比较,肝硬化组、肝癌介入术后组和HBeAg(+)乙肝组PA、CHE及TBA均有显著性差异(P<0.05),HBeAg(-)乙肝组与对照组比较,PA及CHE差异无统计学意义(P>0.05),TBA差异具有统计学意义(P=<0.05);PA及CHE下降程度依次为肝癌介入术后组>肝硬化组>HBeAg(+)乙肝组,而TBA的上升程度依次为肝硬化组>肝癌介入术后组>HBeAg(+)组>HBeAg(-)组。结论 PA、TBA和CHE联合检测是反映肝脏的合成和损害程度,预测肝脏的储备功能的良好指标,可以为临床的治疗和监测提供参考。Objective To verify the clinical value of serum pre-albumin（PA）,total bile acid（TBA） and cholinesterase（CHE） detection in progress of hepatitis B.Methods 141 patients who were detected and identified as progressive hepatitis B and 42 healthy normal controls were selected.Their PA,TBA and CHE were tested by HITACHI 7600-020 automatic analyzer.Results Compared with the control group,there were differences in terms of PA,TBA and CHE in cirrhosis group,liver cancer group and the HBeAg positive group,and the differences had statistical significance（P〈0.05）.There was no statistical significance between the HBeAg negative group and control group in PA and CHE（P〉0.05）;but the difference between the HBeAg negative group and control group in TBA was statistically significant（P〈0.05）.The degree of decline of PA and CHE was arranged respectively as the liver cancer group,the cirrhosis group,and the HBeAg positive group,while the rising degree of TBA was respectively the cirrhosis group,the liver cancer group,the HBeAg positive group,and the HBeAg negative group.Conclusion The joint detection of PA,TBA and CHE is a good detection indicator to reflect the damage degree,the liver synthetic function and reserve function.It can provide reference for clinical treatment and monitoring.

关 键 词：乙型肝炎 前白蛋白 总胆汁酸 胆碱酯酶 

分 类 号：R512.62[医药卫生—内科学]