慢性肾病患者血清及尿透明质酸、层粘连蛋白的表达及临床意义  

Expression and clinical significane of hyaluronic acid and laminin in serum and urinary for detection of patients with chronic kidney disease

作　　者：王茂盛[1] 郝蕾[2] 

机构地区：[1]安徽省太湖县人民医院内一科,安徽太湖246410 [2]内蒙古医科大学,内蒙古呼和浩特010050

出　　处：《中国医药导报》2013年第24期62-64,共3页China Medical Herald

基　　金：内蒙古自治区自然科学基金项目(编号2012MS1181)

摘　　要：目的探讨慢性肾病患者血清及尿透明质酸(HA)、层粘连蛋白(LN)的表达及临床意义。方法选择2010年3月～2012年9月慢性肾病患者60例为病例组,根据肾脏功能情况将病例组分为慢性肾病肾功能正常组(Ⅰ组,n=27),慢性肾病肾功能不全组(Ⅱ组,n=18),慢性肾病肾衰竭组(Ⅲ组,n=13),选择同期健康体检者40例为对照组。采用放射免疫法测定各组调查对象血清及尿中的HA及LN水平,比较对照组与慢性肾病患者的血清及尿HA、LN含量水平差异,同时比较不同肾脏功能状况的慢性肾病患者间血清及尿HA、LN含量的差异。结果Ⅰ组、Ⅱ组、Ⅲ组及对照组血清HA平均值分别为(80.16±11.49)、(114.55±10.74)、(206.78±26.84)、(40.69±8.16)μg/L,LN平均值分别为(136.43±20.45)、(196.68±39.15)、(234.12±33.96)、(102.36±10.94)μg/L,HA、LN水平在4组间差异有高度统计学意义(P<0.01);尿中Ⅰ组、Ⅱ组、Ⅲ组及对照组的HA平均值分别为(90.70±11.94)、(73.19±24.67)、(40.31±33.84)、(102.54±22.64)μg/L,LN平均值分别为(21.48±13.64)、(29.64±18.67)、(53.16±35.16)、(20.34±6.48)μg/L,HA、LN水平在4组间的差异有高度统计学意义(P<0.01)。结论血清及尿HA、LN水平能够反映慢性肾病患者的肾功能情况,可以为慢性肾病的诊断提供依据。Objective To evaluate the expression and clinical significane of hyaluronic acid and laminin in serum and urinary for detection of patients with chronic kidney disease.Methods A total of 60 patients with chronic nephrosis selected from March 2010 to September 2012 were as case group.According to the status of kidney,all the patients were divided into 3 groups,including nephropathy renal function normal group（group Ⅰ,n = 27）,chronic kidney disease renal dysfunction group（group Ⅱ,n = 18） and kidney failure and chronic kidney disease（group Ⅲ,n = 13）,and 40 health controls were regarded as the control group.The HA and LN in the serum and urine were detected by ra dioimmunoassay,and the HA and LN level in serum and urine between the 4 groups were compared.Results The average HA level in the group Ⅰ,Ⅱ and Ⅲ as well as control group were（80.16±11.49）,（114.55±10.74）,（206.78± 26.84）,（40.69 ±8.16） μg/L respectively,and the average LN were（136.43 ±20.45）,（196.68 ±39.15）,（234.12 ±33.96）,（102.36±10.94） μg/L respectively.There was significant difference between the 4 groups in terms of HA and LN（P〈0.01）.The average HA level in the group Ⅰ,Ⅱ and Ⅲ as well as control group were（90.70 ±11.94）,（73.19±24.67）,（40.31 ±33.84）,（102.54 ±22.64） μg/L respectively,and the average LN were（21.48 ±13.64）,（29.64 ±18.67）,（53.16 ± 35.16）,（20.34±6.48） μg/L.Significant difference was also existed in HA and LN between the 4 groups（P〈0.01）.Conclusion The HA and LN in the serum and urine can reflect the kidney function,and can provide the diagnostic markers for chronic kidney disease.

关 键 词：慢性肾病 透明质酸 层粘连蛋白 临床检测 

分 类 号：R692[医药卫生—泌尿科学]