匹多莫德对儿童哮喘患者血清白介素-4和γ-干扰素水平的影响及疗效观察  

Effect and curative observation of Pidotimod on serum interleukin-4 and interferon-γ of children suffering asthma

作　　者：吴延雷 凌杰[2] 

机构地区：[1]浙江省建德市第一人民医院儿科,浙江建德311600 [2]浙江省台州市第一人民医院检验科,浙江台州318020

出　　处：《中国医药导报》2013年第24期101-102,105,共3页China Medical Herald

基　　金：浙江省医药卫生科技计划项目(编号2012ZHB023)

摘　　要：目的探讨匹多莫德对儿童哮喘患者血清白介素-4(IL-4)和γ-干扰素(IFN-γ)水平的影响及疗效观察。方法将2011年7月～2012年3月建德市第一人民医院就诊72例哮喘患儿随机分为匹多莫德组和对照组。两组患儿均按全球哮喘防治创议(GINA)制定的哮喘治疗方案进行治疗。匹多莫德组加用匹多莫德口服液0.4 g,1次/d,连用12周。观察并比较两组患儿治疗12周后血清IL-4和IFN-γ水平的变化及临床疗效。结果治疗12周后,两组患者血清IL-4水平[(0.94±0.25)、(1.23±0.36)μg/L]较治疗前[(1.87±0.51)、(1.91±0.46)μg/L]明显下降(t=3.13、2.31,P<0.01、P<0.05),IFN-γ水平[(14.71±4.12)μg/L、(12.42±3.25)μg/L]较治疗前[(8.07±2.13)μg/L、(7.94±1.87)μg/L]明显上升(t=2.92、2.34,P<0.01、P<0.05),且匹多莫德组下降或上升幅度较对照组更明显(t=2.29、2.14,均P<0.05);匹多莫德组的临床总有效率(91.67%)明显高于对照组(69.44%)(χ2=5.67,P<0.05)。结论匹多莫德治疗儿童哮喘的发作具有较好的临床疗效,作用机制与其能降低血清IL-4水平,提高血清IFN-γ水平,从而调节Th1/Th2细胞因子平衡偏移密切相关。Objective To discuss effect and curative observation of Pidotimod on serum interleukin-4（IL-4） and in terferon-γ（IFN-γ） of children suffering asthma.Methods 72 cases of children suffering asthma from July 2011 to March 2013 collected by the First People＇s Hospital of Jiande City were divided into Pidotimod group and control group at random.The patients in two groups were given the medical treatment in accordance with asthma treatment scheme stipulated by global initiative for asthma（GINA）.In addition,the children in Pidotimod group were given Pido timod oral liquid（0.4 g） one time daily for 12 weeks.The changes of serum interleukin-4（IL-4） and interferon-γ（IFNγ） and clinical curative effect of children in two groups before and after treatment for 12 weeks were observed and compared.Results After medical treatment for 12 weeks,serum IL-4 level of patients in two groups [（0.94 ±0.25）,（1.23±0.36） μg/L] declined obviously than before treatment [（1.87 ±0.51）,（1.91±0.46） μg/L]（t = 3.13,2.31,P〈0.01,P〈0.05）,while IFN-γ level [（14.71±4.12）,（12.42±3.25） μg/L] rose obviously than before treatment [（8.07 ±2.13）,（7.94±1.87） μg/L]（t = 2.92,2.34,P〈0.01,P〈0.05）,and the declining or rising rate in Pidotimod group was much higher than that in control group（t = 2.29,2.14,P〈0.05）.The total clinical efficiency in Pidotimod group（91.67%） was obviously higher than that in control group（69.44%）（χ2=5.67,P〈0.05）.Conclusion Pidotimod has reliable clinical curative effect on asthmatic attack of children,whose mechanism of action may has close relationship with adjust ing the equilibrium shift of Th1/Th2 cytokine,by lowering the serum IL-4 level,and raising serum IFN-γ level.

关 键 词：哮喘 匹多莫德 白介素-4 Γ-干扰素 

分 类 号：R562.2[医药卫生—呼吸系统]