阿仑膦酸钠治疗老年男性骨质疏松患者的效果观察  

Effect observation on Alendronate Sodium in the treatment of elderly male patients with osteoporosis

作　　者：王祥立[1] 平少华[2] 张彪[1] 张晓丽[1] 刘书茂[1] 

机构地区：[1]北京大兴区人民医院骨科,北京102600 [2]河北联合大学附属医院骨科,河北唐山063000

出　　处：《中国医药导报》2013年第24期103-105,共3页China Medical Herald

基　　金：河北省医学科学研究重点课题计划项目(编号20100471)

摘　　要：目的探讨阿仑膦酸钠治疗老年男性骨质疏松患者的治疗效果。方法将98例老年男性骨质疏松患者随机分为观察组(49例)和对照组(49例)。两组患者均给予综合治疗。对照组每天口服钙剂1片(钙尔奇-D,每片含元素钙600 mg,含维生素D 125 U);治疗组除每天口服钙剂l片,同时每周加服阿仑膦酸钠70 mg,连续治疗12个月。观察两组患者治疗前、后骨密度的变化,并进行骨痛缓解率的比较。结果观察组L1-4治疗前、后骨密度分别为(0.87±0.12)、(1.03±0.09)g/cm2,两者比较差异有统计学意义(P<0.05);L2-4治疗前、后骨密度分别为(0.85±0.08)、(1.00±0.08)g/cm2,两者比较差异有统计学意义(P<0.01)。对照组L1-4治疗前、后骨密度分别为(0.88±0.13)、(0.89±0.12)g/cm2,两者比较差异无统计学意义(P>0.05);L2-4治疗前、后骨密度分别为(0.85±0.10)、(0.86±0.11)g/cm2,两者比较差异无统计学意义(P>0.05)。观察组治疗后骨密度较对照组均增高,差异有统计学意义(P<0.05或P<0.01)。观察组骨痛缓解总有效率为95.9%(47/49),对照组为73.5%(36/49),两组比较差异有统计学意义(P<0.05)。结论钙加阿仑膦酸钠治疗老年男性骨质疏松效果好,安全性好,值得临床推广。Objective To discuss the therapeutic effect on Alendronate Sodium in the treatment of elderly male pa tients with osteoporosis.Methods 98 elderly male patients with osteoporosis were divided into observation group（49 cases） and control group（49 cases） randomly.All patients were given comprehensive treatment.Control group was giv en Calcium Tablet one piece oral（Caltrate-D,there were 600 mg calcium in every tablet with 125 U Vitamin D）;treatment group was given Calcium Tablet one piece plus a weekly Alendronate Sodium 70 mg at the same time,which was treated continuously for 12 months.Changes in bone mineral density of two group were observed before and after treatment,and the bone pain remission rate and adverse effects rate were compared.Results Bone mineral density in L1~4 of observation group were（0.87±0.12）,（1.03±0.09） g/cm2 respectively before and after treatment,there was significant difference（P〈0.05）;bone mineral density in L2-4 were（0.85±0.08）,（1.00±0.08） g/cm2 respectively before and after treatment（P〈0.01）.Bone mineral density in L1~4 of control group were（0.88±0.13）,（0.89±0.12） g/cm2 respectively before and after treatment,there was no significant difference（P〈0.05）;bone mineral density in L2~4 were（0.85± 0.10）,（0.86±0.11） g/cm2 respectively before and after treatment,there was no significant difference（P〈0.05）.Bone mineral density of observation group was higher than that of control group after treatment,there was significant differ ence（P〈0.05 or P〈0.01）.Bone pain remission rate of observation group was 95.9%（47/49）,and that of control group was 73.5%（36/49）,there was significant difference（P〈0.05）.Conclusion The therapeutic effect of Calcium plus Alendronate Sodium in the treatment of elderly male patients with osteoporosis is preferable with excellent securi ty,so it is worth to spread.

关 键 词：骨质疏松 老年 男性 阿仑膦酸钠 

分 类 号：R580[医药卫生—内分泌]