HLA-DQA1基因拷贝数目多态性与中国汉族人群类风湿关节炎易感性的研究  

Research between the Polymorphisms of HLA-DQA1 Gene Copy Number and the Susceptibility to Rheumatoid Arthritis in Chinese Han Population

作　　者：陈洁君[1] 吉恒东[2] 郭士成[3] 王一 李媛[3] 金力[3] 王久存[3] 宋新强[3,4] 

机构地区：[1]中国生物技术发展中心,北京100036 [2]泰州市人民医院,江苏泰州225300 [3]复旦大学生命科学学院现代人类学教育部重点实验室,上海200433 [4]信阳师范学院生命科学学院,河南信阳464000

出　　处：《风湿病与关节炎》2013年第8期5-8,共4页Rheumatism and Arthritis

基　　金：上海市科委政府间国际合作项目(11410701800)

摘　　要：目的:探讨中国汉族人群中HLA-DQAl基因拷贝数目多态性与类风湿关节炎发病风险的关系。方法:采用比较基因组杂交和AccuCopy检测技术,检测138例类风湿关节炎患者和191例正常对照者的HLA-DQAl基因拷贝数目。采用Logistic回归模型分析各基因型患者类风湿关节炎的发病风险。结果:HLA-DQAl基因拷贝数目增加的个体,类风湿关节炎发病风险显著升高(P=0.009)。结论:HLA-DQAl基因拷贝数目多态是RA的遗传易感因素,HLA-DQAl基因拷贝数目增加则是类风湿关节炎的危险因素。Objective：To explore the association between the polymorphisms of HLA-DQA1 gene copy number and the onset risk of rheumatoid arthritis in Chinese Han population.Methods：The HLA-DQA1 gene copy numbers of 138 patients with rheumatoid arthritis and 191 controls were detected by comparative genomic hybridization （ CGH ） and AccuCopy assay.Logistic regression model was used to evaluate the impact of this polymorphism on the risk of pathogenesis of rheumatoid arthritis.Results：Carriers with larger number of HLA- DQA1 gene duplication had a significantly increasing risk of rheumatoid arthritis （ P = 0.009 ） .Conclusion：The polymorphism of HLA-DQA1 gene copy number was the predisposing factor of heredity and the increasing number of HLA-DQA1 gene duplication was a risk factor for rheumatoid arthritis.

关 键 词：关节炎 类风湿 HLA—DQAl 拷贝数目多态性 易感性 中国汉族人 

分 类 号：R593.22[医药卫生—内科学]