化痰通腑法治疗中风病痰热腑实证的源流及发展(四)——中风后脑肠轴改变及化痰通腑法治疗痰热腑实证的效应机理  

Origin and development of therapy of resolving phlegm and relaxing bowels for treating syndrome of phlegm heat and bowel excess of stroke ( Ⅳ): changes of brain-gut axis after stroke and effective mechanism of therapy of resolving phlegm and relaxing bowe

作　　者：王永炎[1] 谢颖桢[2] 

机构地区：[1]中国中医科学院,北京100700 [2]北京中医药大学东直门医院

出　　处：《北京中医药大学学报（中医临床版）》2013年第4期1-4,10,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(No.81273693);科技部"十二五"支撑计划(No.2013BA113800)

摘　　要：综述中风病肠道功能紊乱的发病情况及危害,胃肠道功能紊乱脑肠轴机制,中风病痰热腑实证的发生及中药治疗效应机制。目前研究普遍认为:卒中后脑肠肽应激性升高,其升高水平与卒中严重程度呈正相关。痰热腑实证患者胃动素水平较其他证候明显升高。迄今为止对化痰通腑法治疗中风病痰热腑实证的疗效机制主要从调节脑肠轴、抑制炎性反应、改善血液流变学3个方面进行了研究。The authors summed up the onset and damage of the disorder of intestinal iunchon atter stroke, anci discussed the mechanism from the changes of brain-gut axis. The study results showed that after stroke the stress of brain-gut peptide increased and correlated to stroke degree. The level of motilin was significantly higher in the patients with syndrome of phlegm heat and bowel excess than in those with other syndromes. The effective mechanism of therapy of resolving phlegm and relaxing bowels was summarized from regulating brain-gut axis, inhibiting inflammatory reaction and improving hemorrheology.

关 键 词：中风 痰热腑实 脑肠轴 

分 类 号：R255.2[医药卫生—中医内科学]