外用清热利湿中药治疗表皮生长因子受体拮抗剂相关皮疹120例临床研究  被引量:22

EGFRIs-related rash treated with external Chinese medicinal with actions of clearing heat and draining dampness in 120 cases

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作  者:王红岩[1,2] 邹超[3] 崔慧娟[2] 王巍[2] 焦顺昌[4] 李峻岭[5] 

机构地区:[1]北京中医药大学东直门医院,北京100700 [2]中日友好医院 [3]北京中医药大学 [4]解放军总医院 [5]中国医学科学院肿瘤医院

出  处:《北京中医药大学学报(中医临床版)》2013年第4期14-17,共4页Journal of Beijing University of Traditional Chinese Medicine

摘  要:目的观察外用清热利湿中药(自拟中药止痒平肤液)治疗表皮生长因子受体拮抗剂(EGFRIs)相关痤疮样皮疹的疗效,并评价药物的安全性。方法选择经病理学诊断明确的、应用EGFRIs后出现相关痤疮样皮疹、中医证型为"风热型"及"湿热型"的恶性肿瘤患者120例,随机分为治疗组80例和对照组40例。治疗组外用自拟中药止痒平肤液,对照组外用红霉素软膏,连续应用14d。观察治疗前后2组患者皮疹变化以及血常规、肝、肾功能等安全性指标。结果在痤疮样皮疹改善方面治疗组有效57例,稳定23例;对照组有效7例,稳定33例;在瘙痒程度改善上治疗组有效45例,稳定35例;对照组有效3例,稳定37例。经SPSS7.0统计软件分析得出P值均<0.05,具有统计学差异,中药疗效优于红霉素软膏。血常规及肝、肾功能检验均未见明显血液学毒性。未出现与外用药物相关的不良反应。结论自拟中药止痒平肤液用于改善EGFRIs相关痤疮样皮疹及瘙痒效果显著,且无明显不良反应。Objective To observe the curative draining dampness (self-made Zhiyang Pingfu effect of external Chinese medicinal with actions of clearing heat and Ye) on epidermal growth factor receptor inhibitors (EGFRIs)-related acne rash, and review the safety. Methods The patients (n=120) with malignant cancer suffering from acne rash after using EGFRIs diagnosed pathologically (syndrome types of wind heat or dampness heat) were chosen and then randomly divided into treatment group (n=80) and control group (n=40). The treatment group was treated externally with self-made Zhiyang Pingfu Ye, and control group, with erythromycin ointment all for 14 days. The changes of acne rash and safety indexes of routine blood test and liver and kidney functions were observed in two groups before and after treatment. Results In the aspect of abating acne rash, there were 57 cases with curative effect and 23 being stable in treatment group, and 7 with curative effect and 33 being stable in control group. In the aspect of relieving pruritus, there were 45 cases with curative effect and 35 being stable in treatment group, and 3 with curative effect and 37 being stable in control group. The analysis of SPSS 7.0 software showed that all P〈0.05 with statistical significance. The curative effect of Chinese medicinal was better than that of erythromycin ointment. There were no significant hematological toxicity and adverse reactions observed in the tests of routine blood test and liver and kidney functions. Conclusion Self-made Zhiyang Pingfu related acne rash in abating acne rash and relieving pruritus and has Ye has significant curative effect on EGFRIs- no adverse reactions.

关 键 词:表皮生长因子受体拮抗剂 痤疮样皮疹 恶性肿瘤 瘙痒 自拟中药止痒平肤液 清热利湿 中药外用 

分 类 号:R273[医药卫生—中西医结合]

 

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