茵栀黄注射液治疗婴儿肝炎综合征疗效meta分析  

Meta analysis on effects of Yinzhihuang injection in treating infantile hepatitis syndrome

作　　者：刘小雪[1] 姚宝珍[1] 权力[1] 张小芳[1] 庹虎[1] 柏刚[1] 

机构地区：[1]武汉大学人民医院儿科,湖北省武汉市430060

出　　处：《职业与健康》2013年第16期1995-1997,共3页Occupation and Health

摘　　要：目的评价应用茵栀黄注射液治疗婴儿肝炎综合征的疗效。方法计算机检索在Cochrane Central、PubMed、中国知网(CNKI)、万方数据库(Wanfang Data)、维普数据库(VIP),纳入茵栀黄注射液治疗婴儿肝炎综合征的临床随机对照试验,并对其进行质量评价,使用RevMan 5.0进行统计数据分析。结果共纳入4篇随机对照试验。在临床总疗效方面meta分析结果显示,OR=9.48,95%CI(4.05,22.18),在降低血清胆红素方面加权均数差(WMD)=-37.62,95%CI(-50.03,-25.21),缩小肝脏体积方面WMD=-0.86,95%CI(-1.59,-0.13),在降低血清中丙氨酸转氨酶活力(SALT)方面WMD=-20.72,95%CI(-29.38,-12.07),其差异均有统计学意义。结论与常规治疗组相比,茵栀黄注射液结合常规疗法治疗婴儿肝炎综合征疗效更佳,值得推广。[ Objective ] To evaluate the effects of Yinzhihuang injection in treatment of infantile hepatitis syndrome. [ Methods ] Searching Cochrane Central, PubMed, CNKI, Wanfang Data, VIP, randomized controlled trials （RCTs } on Yinzhihuang in treat- ment of infantile hepatitis syndrome were collected, The quality of the included trials was assessed, using RevMan5.0 for statistical analysis. [Results] Four randomized controlled trims were included. Meta-analysis results showed OR =9.48, 95% CI （4.05, 22. 18Jin total clinical efficacy. In aspect of reducing total bilirubin, WMD = -37.62,95% CI（ -50. 03,-25.21 }. In aspect of volume changing of liv- er, WMD =-0.86, 95%CI（-1.59,-0. 13}. In aspect of reducing SALT, WMD =-20.72, 95%CI（-29.38,- 12.07}. All differences were significant. [ Conclusion ] Compared with the routine therapy, Yinzhihuang combined with routine therapy has better efficacy in trea- ting infant hepatitis syndrome, and worthy of promotion.

关 键 词：茵栀黄注射液 婴儿肝炎综合征 META分析 

分 类 号：R725.7[医药卫生—儿科]