基于药性组合模式的3种腰痛方剂聚类分析  

Clustering analysis on three kinds of lumbago prescriptions based on herbal nature combination mode

作　　者：杨丽平[1] 宋庆慧[1] 朱嘉[1] 郎森艳[2] 马渊[1] 孔焕宇[1] 张万强[1] 

机构地区：[1]中国中医科学院望京医院中药药理(骨伤)实验室,北京100700 [2]中国中医科学院望京医院科教处,北京100700

出　　处：《上海中医药杂志》2013年第8期8-10,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：首都医学发展科研基金项目(SF-2007-Ⅰ-06)

摘　　要：目的研究腰痛方剂在"性、味结合归经"层面上的配伍关系,揭示其内在规律。方法筛选古籍文献中治疗肾虚、寒湿和瘀血腰痛的方剂,信息标准化后建立Access数据库,量化处理每个方剂的性味归经,并以此为变量对每种证型的方剂分别聚类分析。结果每种腰痛方剂聚为5个主类时以性微温或温,味辛甘苦,归肾肝脾为主。药性组合特征:肾虚型:甘-微温-肾肝(63%);辛甘苦-微温-肝脾肾(23%);辛苦-温-肾脾(4%);辛甘-热-肾脾心(4%);苦甘-微寒-肾肝(3%)。寒湿型:苦辛-微温-肾肝(31%);辛甘-温-肾肝(26%);辛苦-温-脾胃(14%);甘-微温-肝肾(12%);甘-温-脾胃(11%)。瘀血型:辛苦-微温-肝(27%);甘苦-微温-肾肝(23%);辛甘-温-肝肾(21%);辛苦-微温-脾肾肝(13%);辛-温-肝脾(7%)。结论方剂的组合药性聚类能够反映治则治法的科学内涵,可为配伍规律的研究提供新思路。Objective To study the compatible relationship of lumbago prescriptions based on their nature, taste and meridian distribution and reveals its inherent laws. Methods Screened three kinds of lumbago prescriptions in the ancient documents （ lumbago due to kidney deficiency, cold dampness or blood stasis）. The access database was established after standardized information. The nature, taste and meridian distribution were used as the variable quantities for clustering analysis. Results Most of the prescriptions were clustered into five categories. The prescriptions are mainly natured by tepid or warm, and the tastes are acrid, sweet and bitter, and mainly acted on the kidney, liver and spleen meridian. The medical nature and combination in each pattern are as follows： kidney deficiency pattern ： sweet-tepid-kidney, liver （63%） ; acrid, sweet and bitter-tepid-liver, spleen and kidney （ 23 % ） ; acrid, bitter-warm-kidney, spleen （4%） ; acrid, sweet-hot-kidney, spleen, heart （4%） ; bitter, sweet-slightly cold-kidney, liver （3%）. Cold dampness pattern： bitter, acrid-tepid-kidney, liver（31% ） ; acrid, sweet-warm-kidney, liver （26%）; acrid, bitter-warm-spleen, stomach （14%）; sweet-tepid-liver, kidney（ 12% ）; sweet-warm-spleen, stomach（ 11% ）; blood stasis pattern ： acrid, bitter-tepid-liver （27%） ; sweet, bitter-tepid-kidney, liver （23 % ） ; acrid, sweet-warm-liver, kidney （ 21% ） ; acrid, bitter-tepid-spleen, kidney, liver （ 13 % ） ; acrid-warm-liver, spleen （7%）. Conclusion Cluster of herbal nature combination of prescription can reflect the scientific connotation of its therapeutic principle. It provides a new approach for the research of compatibility rule of prescription.

关 键 词：药性量化 方剂药性 药性配伍 聚类分析 

分 类 号：R289[医药卫生—方剂学]