异莲心碱抗实验性心律失常作用及对豚鼠心肌动作电位的影响  

Effects of Isoliensinine on Experimental Arrhythmia and Myocardium Action Potential of Guinea Pig

作　　者：张帆[1] 王嘉陵[1] 钱家庆[1] 

机构地区：[1]同济医科大学药理教研室,武汉430030

出　　处：《中草药》2000年第10期753-755,共3页Chinese Traditional and Herbal Drugs

基　　金：卫生部科研基金!(No.98DJ15 -87)资助项目

摘　　要：采用 4种药物及冠状动脉结扎诱发的在体动物心律失常模型 ,比较了异莲心碱和奎尼丁的抗心律失常效果 ,证实了异莲心碱对抗多种实验性心律失常 ,且作用优于奎尼丁。采用标准微电极法 ,研究了异莲心碱对豚鼠右心室乳头状肌的快、慢反应动作电位的影响 ,结果表明异莲心碱降低 APA、Vm ax,缩短 APD5 0 。提示其抗心律失常作用机制可能与阻滞 Ca2 + 、Na+ 电流有关。Antiarrhythmic effect of isoliensinine (IL) was studied on experimental arrhythmic mo dels induced by coronary artery ligation and 4 different arrhythmogenic drugs in comparison with quinidine (Qu) Results of the study showed that the antiarrhythmic potency of IL was stronger than that of Qu at the same dosage The effects of IL on fast and slow response action potentials of myocardium were observed in guinea pig papillary muscles by standard microelectrode technique, which showed that IL could reduce APA and Vmax and shorten the APD 50 The results suggested that the antiarrhythmic mechanism of IL is related to its non specific inhibition of the currents of Na + and Ca 2+

关 键 词：异莲心碱 心律失常 动作电位 动物模型 中药 

分 类 号：R259.417[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]