Nucleophilic Trifluoromethylthiolation of Allylic Bromides： A Facile Preparation of Allylic Trifluoromethyl Thioethers  

作　　者：Jianwei Tan Guoting Zhang Yangli Ou Yaofeng Yuan Zhiqiang Weng 

机构地区：[1]Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China

出　　处：《Chinese Journal of Chemistry》2013年第7期921-926,共6页中国化学（英文版）

基　　金：Acknowledgement This work was supported by National Natural Science Foundation of China （No. 21072030）, Research Fund for the Doctoral Program of Higher Education of China （No. 20123514110003）, the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry （No. 2012-1707）, and Fuzhou University （Nos. 022318, 022494）.

摘　　要：A facile preparation of allylic trifluoromethyl thioethers was achieved by using a copper reagent. The reaction of （bpy）Cu（SCF3） with various allylic bromides afforded the desired trifluoromethylthiolation products in good to excellent yields with high stereo- and regioselectivity. Common functional groups such as alkyl, alkoxy, trifluoromethyl, nitro, halides and geranyl are well tolerated.A facile preparation of allylic trifluoromethyl thioethers was achieved by using a copper reagent. The reaction of （bpy）Cu（SCF3） with various allylic bromides afforded the desired trifluoromethylthiolation products in good to excellent yields with high stereo- and regioselectivity. Common functional groups such as alkyl, alkoxy, trifluoromethyl, nitro, halides and geranyl are well tolerated.

关 键 词：trifluoromethylthiolation allylic halides COPPER 

分 类 号：O623.82[理学—有机化学] O626[理学—化学]