我院2007-2012年抗菌药物临床应用对肺炎克雷伯菌耐药性变迁的影响  

Influence of clinical use of antibiotics on drug resistance of Klebsiella pneumoniae in our hospital from 2007 to2012

作　　者：贾秀芹[1] 陈建忠[1] 庞峰 李艳华 蒋陆霞[1] 

机构地区：[1]聊城市人民医院药学部,252000 [2]检验科

出　　处：《国际医药卫生导报》2013年第17期2663-2666,共4页International Medicine and Health Guidance News

基　　金：聊城市卫生局科研基金项目（2012-35）

摘　　要：目的探讨抗菌药物使用对肺炎克雷伯菌耐药率变化的影响，为临床合理使用抗菌药物提供理论依据。方法回顾性分析我院2007-2012年抗菌药物年用量及肺炎克雷伯菌耐药率变化趋势，计算用药频度（DDDs），采用Pearson相关分析法对耐药率与DDDs进行分析。结果2007-2008年肺炎克雷伯菌对大部分抗菌药物耐药率较高，2009年开始呈下降趋势；自2010年多数抗菌药物DDDs有不同程度下降；头孢他啶、头孢哌酮／舒巴坦、头孢吡肟、阿米卡星、左氧氟沙星和亚胺培南的DDDs与肺炎克雷伯菌耐药率呈高度正相关（r〉0．800，P〈0．05）。结论抗菌药物用量与肺炎克雷伯菌耐药率之间存在一定相关性，应加强抗菌药物临床应用管理。Objective To provide a theoretical basis for the rational use of antimicrobial drugs discussing the influence of the clinical use of antibiotics on drug resistance of Klebsiella pneumoniae. Methods The annual consumption of antimicrobial agents and the change trend of drug resistance of K. pneumoniae in our hospital from 2007 to 2012 were retrospectively analyzed, then the DDDs of antibiotics were calculated. The correlation between the drug resistance of K. pneumoniae and the DDDs of antibiotics were analyzed by pearson analysis. Results The resistance rates of K. pneumoniae to most of the antimicrobial were higher from 2007 to 2008 and then decreased since 2009. The DDDs of most antimicrobial had decreased in different degrees since 2010. The resistance rate of K. pneumoniae highly and positively correlated with the DDDs of ceftazidime, cefoperazone/sulbactam, cefepime, amikacin, levofloxacin, and imipenem （r 〉 0.800,P 〈 0.05）. Conclusions The drug resistance of K. pneumoniae correlates with the consumption of antibiotics, so the management of antimicrobial application should be strengthen.

关 键 词：抗菌药物 肺炎克雷伯菌 用药频度 耐药性 

分 类 号：R446.5[医药卫生—诊断学]