血必净对急性胰腺炎患者血清肿瘤坏死因子-α、白介素-1β及白介素-6质量浓度的影响  

Effect of Xuebijing injection on serum concentrations of TNF-α,IL-1β and IL-6 in patients with acute pancreatitis

作　　者：孙长江[1] 范辉[2] 葛建彬[1] 

机构地区：[1]江苏省南通市第二人民医院药剂科,江苏南通226002 [2]江苏省南通市第二人民医院消化科,江苏南通226002

出　　处：《实用临床医药杂志》2013年第9期83-85,90,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨血必净改善急性胰腺炎患者炎症反应的可能机制。方法选取急性胰腺炎发作且24 h以内入院的患者79例,随机分为血必净治疗组(n=41)和常规治疗组(n=38),同时选取33例健康体检人员作为对照组。3组分别于入院后第1、3天和第1、2周抽取血液,采用酶联免疫吸附剂测定法(ELISA)测定血清细胞因子肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)及白介素-6(IL-6)的质量浓度。结果急性胰腺炎患者血清TNF-α、IL-1β及IL-6质量浓度在急性胰腺炎发作后快速上升,第1天到达峰值;至发病第3天,其TNF-α、IL-1β及IL-6质量浓度仍高于对照组;至第1周,其血清TNF-α、IL-1β质量浓度仍高于对照组。和常规治疗组相比,血必净治疗组在第3天及第1周时,TNF-α质量浓度显著降低;IL-1β和IL-6质量浓度在第3天即显著降低。结论血必净在早期能够降低急性胰腺炎患者血清细胞因子TNF-α、IL-1β及IL-6的质量浓度,通过抑制炎症反应来保护胰腺及其他器官,这可能是血必净治疗急性胰腺炎的作用机制之一。Objective To investigate the effects of Xuebijing injection on serum concentrations of TNF-α,IL-1β and IL-6 in patients with acute pancreatitis（AP）.Method A total of 79 patients were randomly divided into Xuebijing group（n=41） and conventional treatment group（n=55） with 33 healthy volunteers as a control group.ELISA was applied to measure the serum concentration of these cytokine： TNF-α,IL-1β and IL-6 at different time points（1 d,3 d,1 w,2 w after the onset of AP）.Results The serum of concentrations of TNF-α,IL-1β and IL-6 reached the maximum on the first day when AP occurred,the serum concentration of TNF-α,IL-1β and IL-6 were still at high level at the third day after occurrence compared with the control group（P0.05）.And at the end of the first week,serum concentration of TNF-α and IL-1β were still higher than the control group（P0.05）.Compared with the conventional treatment group,serum concentrations of TNF-α of Xuebijing group were significantly decreased from the third day to the seventh day,and the serum concentrations of IL-1β and IL-6 were significantly reduced on the third day（P0.05）.Conclusion Xuebijing can reduce serum concentrations of TNF-α,IL-1β and IL-6 at the early stage of the AP course.Inhibiting the inflammation may be the molecular mechanisms through which Xuebijing treats AP.

关 键 词：血必净 急性胰腺炎 肿瘤坏死因子-Α 白介素-1Β 白介素-6 

分 类 号：R657.5[医药卫生—外科学]