上海市23例手足口病重症病例发病危险因素研究  

Study on Risk Factors Associated with 23 Severe Case of Hand-Foot-Mouth Disease(HFMD)in Shanghai

作　　者：王琳[1] 邓雪[1] 张政熙[1] 曹慎[1] 龚刚[1] 乔鹏[1] 王袁[1] 

机构地区：[1]上海市杨浦区疾病预防控制中心,上海200090

出　　处：《疾病监测与控制》2013年第8期465-467,共3页Journal of Diseases Monitor and Control

基　　金：2010年卫生部公共卫生专项资金项目

摘　　要：目的掌握上海地区手足口病重症病例发病危险因素,探索早期识别重症病例的参考指标,加强预测,降低重症病例发生的风险。方法按照1:2比例对23名手足口病重症病例及46名普通病例进行现场问卷调查并采集患儿咽拭子、粪便标本及疱疹液开展病原学检测。结果手足口病重症病例发生的风险随年龄的增加及首次就诊的医疗机构级别升高而下降;发病到首次就诊时间间隔长及EV71感染发生重症病例的风险分别是对照组的5.537倍和79.644倍。结论低年龄、首次就诊医疗机构类型、发病到首次就诊时间间隔及EV71感染可作为早期识别重症病例的参考指标。Objective To recognize the risk factors of Severe Case of Hand-Foot-Mouth Disease （HFMD） in Shanghai,and to seek out clues for targeted interventions to prevent the occurrence of severe case, Methods A total of 23 severe cases and 46 mild cases of HFMD were enrolled according to the ratio of 1：2 in this matched case-control study, and Specimens of throat swabs anal swabs and herpes fluids were collected to detect nucleic acid of erterovirus. Results the risk of developing severe cases of HFMD was lowed by elder age and by higher level hospital, the risk of developing severe cases with the time of froming ill to going to hospital and EV71infection was 5.537, 79.644 times of mild cases respectively. Conclusion It was concluded that lower age and level hospital and the time of froming ill to going to hospital and EV7 linfection could be used as the initial indicatiors to identify severe cases.

关 键 词：手足口病 重症病例 危险因素 病例对照 

分 类 号：R512.5[医药卫生—内科学]