Castleman病合并肾脏损害5例临床病理学分析  

Castleman's disease with impaired renal function: a pathological study of 5 cases

作　　者：隋燕霞[1] 王鸿雁[1] 杨喆[1] 李晓峰[1] 

机构地区：[1]西安交通大学医学院第一附属医院病理科,西安710061

出　　处：《临床与实验病理学杂志》2013年第8期859-862,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨Castleman病合并肾脏损害的病理学特征。方法对5例Castleman病合并肾脏损害进行临床病理学观察,分析Castleman病与肾脏损害之间的相关性。结果 5例患者淋巴结病变均为多中心型Castleman病。病理类型:4例浆细胞型,1例透明血管型;按引起肾脏损害的组织病理类型分类为:2例系膜增生性肾小球肾炎、2例急性间质性肾炎、1例膜增生性肾小球肾炎。结论 Castleman病引起肾脏损害较少见,如遇到多部位淋巴结肿大,同时又有肾脏损害的患者,应及早行肿大淋巴结活检及肾脏穿刺活检,明确病理诊断及两者之间的相互关系,以便得到及时准确的治疗。Purpose To explore the pathological features of Castleman＇ s disease with impaired renal function. Methods Pathological observation was conducted in 5 patients with Castlema＇ s disease with impaired renal function. The relationship between the Castlema＇ s disease and the impaired renal function was analyzed. Results The lymph node pathological changes in 5 cases were all in accordance with multicentric Castleman＇ s disease. According to histopathologic subclassification, four cases were plasma cell type, and one case was hyaline-vascular type. The pathological changes of kidney damage in 2 cases were mesangioproliferative glomerulonephritis, the changes in 2 cases were acute tubulointerstitial nephropathy, and the change in 1 case was membranoproliferative glomerulonephritis. Conclusions Renal dysfunction impaired by the Castlema＇ s disease is rarely seen. Therefore, it is necessity to confirm the diagnosis through histopathological examination by lymph node and renal biopsy if multiple lymph nodes enlargement concurrently occurs with the impaired renal function.

关 键 词：CASTLEMAN病 肾脏损害 病理 活检 

分 类 号：R551.2[医药卫生—血液循环系统疾病]