非酒精性脂肪肝病合并高尿酸血症患者临床特点及危险因素分析  

Clinical characteristics and risk factors of patients with nonalcoholic fatty liver disease and hyperuricemia

作　　者：侯丽丽[1] 张宝[1] 管石侠[1] 唐芸[1] 蒋建华[1] 

机构地区：[1]安徽医科大学第一附属医院临床营养科,合肥230022

出　　处：《安徽医科大学学报》2013年第9期1052-1055,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:11040606M200)

摘　　要：目的探讨非酒精性脂肪肝病(NAFLD)合并高尿酸血症(HUM)患者各项临床指标特点及危险因素。方法选择97例单纯NAFLD患者(对照组)及71例NAFLD合并HUM患者(研究组),比较两组相关人体成分测定指标、血压、血脂、血糖、空腹胰岛素、胰岛素抵抗指数;采用Logistic回归分析评价NAFLD患者发生HUM的危险因素。结果与对照组比较,研究组体质指数(BMI)、腰围(WC)、腰臀比(WHR)、内脏脂肪面积(VFA)、三酰甘油(TG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)均显著升高,高密度脂蛋白胆固醇(HDL-C)显著降低(P<0.05);研究组代谢综合征(MS)检出率明显高于对照组(P<0.05);相关分析结果表明,VFA与BMI、体脂含量、WC、WHR、血压、血糖(FBG)、TG、尿酸(UA)、FINS、HOMA-IR呈正相关,与HDL-C呈负相关(P<0.05);Logistic回归分析显示,高VFA和高TG血症是NAFLD发生HUM的危险因素。结论 NAFLD合并HUM患者较单纯NAFLD患者血脂紊乱及胰岛素抵抗(IR)程度加重,患MS风险升高,高VFA和高TG血症是NAFLD发生HUM的危险因素。Objective To explore clinical characteristics and risk factors in patients of nonalcoholic fatty liver disease（NAFLD） complicated with hyperuricemia（HUM）.Methods 97 cases（control group） of NAFLD patients uncomplicated with HUM and 71 cases（study group） of complicated with HUM were researched.Some of body composition measurement index,blood pressure,blood lipids,fasting blood glucose,fasting insulin and insulin resistance index were detected.Logistic regression analysis was used in the evaluation of NAFLD patients with risk factors for HUM.Results Compared with control group,body mass index（BMI）,waist circle（WC）,waist to hip ratio（WHR）,visceral fat area（VFA）,triglyceride（TG）,fasting insulin（FINS） and HOMA-IR were significantly increased in study group while high density lipoprotein-cholesterol（HDL-C） was reduced obviously（P 0.05）.The detection rate of metabolic syndrome（MS） in study group was significantly higher than that in control group（P 0.05）.The correlation analysis showed that VFA was positively correlated with BMI,body fat content,WC,WHR,SBP,DBP,TG,FINS,and HOMA-IR,negatively correlated with HDL-C（P 0.05）.Logistic regression analysis showed that high visceral fat area and hypertriglyceridemia were risk factors of NAFLD patients complicated with HUM.Conclusion Dyslipidemia and insulin resistance of NAFLD patients complicated with HUM are heavier than those of NAFLD patients.Risk of MS is also higher in NAFLD patients complicated with HUM.High visceral fat area and hypertriglyceridemia are risk factors of HUM for NAFLD.

关 键 词：非酒精性脂肪肝 高尿酸血症 代谢综合征 

分 类 号：R589.7[医药卫生—内分泌]