维持血液透析患者微炎症与营养及血脂的关系  

Microinflammation associated with dyslipidemia and nutritional status in maintenance hemodialysis patients

作　　者：汪鹏[1] 张翠萍[2] 任伟[1] 兰雷[1] 倪力军[1] 

机构地区：[1]安徽医科大学附属省立医院肾脏内科,合肥230001 [2]安徽医科大学附属省立医院中心实验室,合肥230001

出　　处：《安徽医科大学学报》2013年第9期1099-1102,共4页Acta Universitatis Medicinalis Anhui

摘　　要：目的探讨维持血液透析(MHD)患者微炎症与营养及血脂的关系。方法 39例MHD患者按血超敏C反应蛋白(hs-CRP)分为高CRP组(≥12 mg/L,19例)和低CRP组(<12 mg/L,20例)。比较两组营养状况及血脂水平差异。结果①高CRP组血白蛋白水平较低CRP组低[(42.14±2.59)g/L vs(44.20±3.32)g/L,P<0.05];②高CRP组血总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平较低CRP组高,高密度脂蛋白胆固醇(HDL-C)水平较低CRP组低(P<0.05);③hs-CRP与TC(rs=0.615 7,P<0.01)、TG(rs=0.595 6,P<0.01)、LDL-C(rs=0.433 1,P<0.01)呈正相关。结论 MHD患者微炎症与白蛋白水平、致动脉硬化脂代谢紊乱相关。Objective To evaluate the relationship between microinflammation,nutrional status,and dyslipidemia in maintenance hemodialysis（MHD） patients.Methods 39 MHD patients were recruited in the study.The enrolled patients were divided into high CRP group（hs-CRP≥12 mg/L,n=19）and low CRP group（hs-CRP12 mg/L,n=20）.Comparison about nutritional status,acid-base status and blood lipid level were made between two groups.Meanwhile,the correlation analysis between inflammatory markers and parameters of nutritional status and blood lipid level were made.Results ① Compared with patients in low CRP group,high CRP group had significant serum total cholesterol,triglyceride,LDL-C,while low CRP group had significant lower serum albumin and HDL-C;② There were no significant difference in serum total protein,pre-albumin,or parameters of arterial blood gas analysis;③ hs-CRP correlated positively with serum total cholesterol and triglyceride;④ IL-6 correlated positively with predialysis pH value,and iPTH.Conclusion Microinflammation is associated with serum albumin and atherogenic dyslipidemia in MHD patients.

关 键 词：血液透析 微炎症 蛋白质-能量营养不良 血脂 

分 类 号：R459.5[医药卫生—治疗学]