Studies on the Calcium Antagonist Action of Arctigenin  

作　　者：Gao Yang Kang Tingguo Zhang Xiaoyu 

机构地区：[1]Liaoning College of TCM ,Shenyang 110032

出　　处：《中草药》2000年第10期758-762,共5页Chinese Traditional and Herbal Drugs

摘　　要：对牛蒡苷元 (ACT)的钙拮抗作用进行探讨 ,为确认 ACT是牛蒡子解表功能的有效成分提供实验依据。描记给 ACT前后 ,各标本对 KCl或 Ca Cl2 诱发收缩的量效曲线 ,按 Scott法计算 PD'2 ;测定给 ACT后 ,标本对乙酰胆硷 (Ach)诱发的两相收缩的抑制百分率。 ACT对离体大鼠气管、结肠、肺动脉、胸主动脉平滑肌由 KCl引起的收缩产生非竞争性拮抗作用 ,其 PD'2 分别为 4.0 1,5 .11,5 .98,6 .0 5 ;ACT和维拉帕米 (Verapamil)相似 ,对离体豚鼠气管平滑肌由 Ca Cl2 引起的收缩产生非竞争性拮抗作用 ,其 PD'2 分别为 4.0 4,5 .6 2 ;对 Ach诱发的两相收缩只明显抑制第一时相收缩 ,抑制率分别为 6 6 .14% ,81.42 % .ACT对平滑肌的松弛作用可能是由于阻滞电压依赖性钙通道和内钙释放所致 ;ACT是牛蒡子解表功能的有效成分。The calcium antagonist action of arctigenin (ACT) was studied in order to verify the effect of Fructus Arctii for the relieve of exterior syndrome Muscular contraction of isolated rat trachea, colon, pulmonary artery and thoracic aorta induced by KCl, that of guinea pig trachea induced by CaCl 2, before and after the addition of ACT were assessed and their contraction response curves drawn and PD'2 calculated according to Scott The inhibition rate of two phase contraction of guinea pig trachea induced by acetylcholine chloride (Ach) in comparison with verapamil (VER) was calculated Results of the study showed that ACT could non compatitively antagonize the muscular contraction of the test specimens with PD' 2 of 4 01, 5 11, 5 98 and 6 05 respectively Similar to VER, ACT could non competitively antagonize the isolated guinea pig trachea with PD'2 of 4 04 and 5 62 respectively Both of them could inhibit the first phase contraction induced by Ach with inhibition rates of 66 14% and 81 42% respectively It was concluded that ACT, as the active constituent of Fructus Arctii, relaxed smooth muscle contraction by blocking the potential dependant Ca 2+ channel and the internal release of Ca 2+

关 键 词：牛蒡苷元 平滑肌收缩 钙拮抗剂 中医药治疗 大鼠 

分 类 号：R259.43[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]