双炔失碳酯对人早孕绒毛蜕膜组织细胞分泌功能的影响  

The effects of anordrin on the endocrine function of chorionic and decidual cells in early human pregnancy

作　　者：刘芳 于俊荣 张凤娥 樊瑞琴 齐惠敏 王兰素[2] 王华芝[2] 

机构地区：[1]河北省计划生育科学技术研究所,石家庄050071 [2]河北医科大学第二附属医院,石家庄050000

出　　处：《生殖医学杂志》2000年第5期284-288,共5页Journal of Reproductive Medicine

基　　金：国家计划生育药具重点实验室资助! (B2 - 98- 5 ;98- 19- 1)

摘　　要：本实验以绒毛、蜕膜组织细胞培养为模型 ,用放射免疫测定方法 ,观察了双炔失碳酯对绒毛、蜕膜组织细胞分泌功能的影响。结果 :培养的绒毛、蜕膜组织细胞中加入系列浓度的双炔失碳酯后 2 4和 48h,h CG、E2 、P均明显降低 (P<0 .0 1 ,P<0 .0 5 ) ,PGF2α明显增高 (P<0 .0 1 ,P<0 .0 5 )。表明 ,双炔失碳酯可直接作用于人绒毛、蜕膜组织 ,抑制h CG、E2 、P的产生 ,刺激 PGF2α的合成。结果提示 ,绒毛、蜕膜是双炔失碳酯抗早孕时 ,主要作用环节之一。Objectives: To examine the effects of anordrin on the endocrine function of chorionic and decidual cells in vitro and to investigate the mechanisms of termination of pregnancy of anordrin. Methods: The project was studied by using tissue cells culture and RIA. Results: Anordrin inhibited the production of hCG、E 2、P and stimulated the synthesis of PGF 2α in chorionic and/or decidual tissue cells in vitro( P<0.01,P<0.05 ). Conclusion: The results indicate that chorion and decidua serve as one of the primary sites through which anordrin exerts the effect of termination for early pregnancy.

关 键 词：双炔失碳酯 绒毛 蜕膜 内分泌功能 终止妊娠 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]