第6秒用力呼气容积替代用力肺活量诊断中重度慢性阻塞性肺疾病效果研究  

FEV_6 AS AN ALTERNATIVE FOR FVC IN DIAGNOSIS OF MODERATE-SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE

作　　者：李幸彬[1] 杜秀然[2] 杨凤[3] 王显雷[1] 耿书军[1] 陈素丽[1] 

机构地区：[1]河北省胸科医院结核内科,河北石家庄050041 [2]河北省胸科医院胸外科,河北石家庄050041 [3]河北省胸科医院肺功能室,河北石家庄050041

出　　处：《河北医科大学学报》2013年第8期888-891,共4页Journal of Hebei Medical University

基　　金：河北省科技支撑计划项目(11276103D-5)

摘　　要：目的评估第6秒用力呼气容积(forced expiratory volume in six seconds,FEV_6)替代用力肺活量(forced vital capacity,FVC)诊断中重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的效果。方法对2010年8月—2012年8月河北省胸科医院287例舒张前、舒张后呼气时间达6s以上的中重度COPD患者的肺功能检查结果进行回顾性分析,对舒张后的FEV_6与FVC、FEV_1/FEV_6与FEV_1/FVC进行相关性分析,以FEV_1/FEV_6<70%为标准,判定诊断效果。结果 FEV_6与FVC、FEV_1/FEV_6与FEV_1/FVC高度相关(r=0.989,r_s=0.979,P<0.05)。以FEV_1/FEV_6<70%为诊断标准,287例患者中273例诊断为COPD,诊断率为95.12%。结论 FEV_1/FEV_6与FEV_1/FVC高度相关,FEV_1/FEV_6诊断中重度COPD与FEV_1/FVC具有高度一致性,FEV_6可以有效替代FVC用于诊断中重度COPD。Objective To determine the efficacy of forced expiratory volume in six seconds （FEV6 ） as an alternative for forced vital capacity （FVC） in the diagnosis of moderate-severe chronic obstructive pulmonary disease （COPD）. Methods The spirometric examinations of 287 moderate-severe COPD patients were analyzed, FEV6 was measured on volume-time curves. The correlation between FEV6 and FVC,FEV1/FVC and FEV1/FEV6 was evaluated by Pearson test and Spearman test. FEV1/FEV6 〈 70% was considered as the standard for obstruction to evaluate the diagnosis effect. Results FEV~ and FVC,FEV1/FEV6 and FEVJFVC ratios were highly correlated （ r = 0. 989, rs = 0. 979, P 〈 0.05 ）. Considering FEVJFEV6 〈 70% as the standard for obstruction, 95. 12% patients （273/287） were diagnosed COPD. Conclusion There are strong correlation between FEV6 and FVC, FEV1/FVC and FEVI/FEV6. FEV6 can be a valid alternative for FVC in the diagnosis of moderate-severe chronic obstructive pulmonary disease.

关 键 词：肺疾病 慢性阻塞性 用力呼气量 呼吸功能试验 

分 类 号：R563[医药卫生—呼吸系统]