脂肪细胞因子与2型糖尿病关系的Meta分析  

RELATIONSHIP BETWEEN ADIPOCYTOKINES AND TYPE 2 DIABETES:A Meta-ANALYSIS

作　　者：曹丹丹[1] 李昱[2] 石军梅[3] 贾金海[1] 高娉[1] 张晓琳[1] 

机构地区：[1]河北医科大学公共卫生学院流行病与卫生统计学教研室,河北石家庄050017 [2]河北医科大学临床学院实验中心生理教研室,河北石家庄050017 [3]河北医科大学第四医院肿瘤内科,河北石家庄050011

出　　处：《河北医科大学学报》2013年第8期902-904,共3页Journal of Hebei Medical University

基　　金：河北省卫生厅医学科学研究重点课题指导计划(20090320)

摘　　要：目的了解血清各种脂肪细胞因子水平与2型糖尿病的关系。方法通过检索Pubmed数据库、中国期刊网全文数据库(China National Knowledge Infrastructure,CNKI)等搜集文献,应用Meta分析的方法对纳入文献的结果进行统计量合并,计算标准化均数差(standard mean difference,SMD)或加权均数差(weighted mean difference,WMD)及其95%可信区间(confidence interval,CI)。结果共纳入73篇文献,研究了脂联素、抵抗素、瘦素、内脂素和肿瘤坏死因子α与2型糖尿病的关系。5种脂肪细胞因子与2型糖尿病均相关,其SMD/WMD(95%CI)分别为-1.65(-1.85～-1.45)、1.42(1.31～1.54)、0.21(0.14～0.27)、2.36(2.24～2.48)和1.70(1.55～1.85)。结论脂联素、抵抗素、瘦素、内脂素和肿瘤坏死因子α均与2型糖尿病具有明显关联性。Objective To understand the association between serum adipocytokines and type 2 diabetes. Methods The references were retrieved through the database of Pubmed, Medline, CBM and China National Knowledge Infrastructure（CNKI） , the standard mean difference （SMD） or weighted mean difference, WMD） and 95% CI were calculated using Meta-analysis. Results Seventy-three studies were included in which the relationship was assessed between five adipoeytokines and type 2 diabetes such as adiponectin, resistin, leptin, visfatin and tumor necrosis factor-or （TNF-α）. The results of meta-analysis showed that all of the five adipocytokines had a relationship with type 2 diabetes. The SMD/WMD and 95%Clwere -1.65 （ -1.85- -1.45）,1.42 （1.31 -1.54）,0.21 （0.14-0.27）,2.36 （2.24- 2.48 ） and 1. 70 （ 1.55 - 1. 85 ） , respectively. Conclusion There is a correlation between serum adipocytokines and type 2 diabetes.

关 键 词：糖尿病 2型 脂细胞 META分析 

分 类 号：R587.1[医药卫生—内分泌]