进食对美欧卡霉素药代动力学和生物利用度的影响  

Influence of food on pharmacokinetics and bioavailability of miocamycin in normal volunteers after single oral administration

作　　者：徐榕青[1] 邓思珊[1] 郭舜民[1] 

机构地区：[1]福建省医学科学研究所药物研究室,福建福州350001

出　　处：《中国药学杂志》2000年第11期758-760,共3页Chinese Pharmaceutical Journal

摘　　要：目的　比较研究空腹、餐后单剂量po美欧卡霉素的药代动力学和生物利用度。方法　采用交叉给药方案 ,10名健康受试者空腹或餐后单剂量po 6 0 0mg美欧卡霉素 ,用HPLC测定血药浓度 ,SCIENTIST程序拟合药代动力学参数 ,t检验比较组间差异 ,双单侧t检验评价生物等效性。结果　空腹和餐后单剂量给药的药时曲线均符合单室模型 ,达峰时间tmax分别为 (0 .6 3± 0 .11) ,(1.0 2± 0 .31)h ,峰浓度cmax分别为 (2 .36± 0 .35 ) ,(1.82± 0 .32 ) μg·ml- 1 ,消除半衰期t1 2 分别为 (1.31± 0 .11) ,(2 .0 3± 0 .19)h ,药时曲线下面积AUC分别为 (6 .2 0± 1.2 8) ,(6 .88± 1.46 ) μg·h·ml- 1 。结论　进食使美欧卡霉素的吸收速度减慢、消除半衰期延长 ,但对吸收总量无显著影响 ,以AUC为指标进行评价 ,两者生物等效。OBJECTIVE To compare the pharmacokinetics and bioavailability of miocamycin under conditions of fasting and after meal.METHODS A single oral dose of miocamycin 600 mg was given to 10 healthy volunteers under the conditions of fasting and after meal in a crossover study.Serum miocamycin concentration was determined by HPLC.RESULTS The concentration time profile of miocamycin fitted to one compartment model and the pharmacokinetic parameters were: t max =(0.63±0.11) and (1.02±0.31) h, c max =(2.36±0.35) and (1.82±0.32) μg·ml -1 , t 1/2 =(1.31±0.11) h and (2.03±0.19) h, AUC =(6.20±1.28) and (6.88±1.46) μg·h·ml -1 in fasting and after meal conditions,respectively.The absorption rate of miocamycin was delayed and the peak concentration was reduced,with a long elimitration half time after meal.But the bioavailability of miocamycin had no significant difference.CONCLUSION Miocamycin was bioequivalence between the conditions of fasting and after meal.in terms of AUC .

关 键 词：美欧卡霉素 药代动力学 生物利用度 

分 类 号：R978.15[医药卫生—药品] R969.1[医药卫生—药学]