主客体包结法选择分离补骨脂中的异补骨脂素  

SELECTIVE ISOLATION OF ISOPSORALEN FROM CRUDE EXTRACT OF PSORALEA CORYLIFOLIA . L BY USING INCLUSION METHOD OF HOST GUEST MOLECULES

作　　者：郭文生[1] 郭放[1,2] 许中兴[3] 郑启泰[2] 吕扬[2] 

机构地区：[1]辽宁大学化学科学与工程学院,辽宁沈阳110036 [2]中国医学科学院,中国协和医科大学药物研究所,辽宁鞍山114002 [3]鞍山钢铁学院应用化学系,北京100050

出　　处：《药学学报》2000年第11期864-867,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金!(39370 810 )

摘　　要：AIM To isolate the chemical components from extracted crude of Psoralea corylifolia L. METHODS Applicate the function of molecular recognition in supramolecular chemistry, use 1,1,6,6 tetraphenylhexa 2,4 diyne 1,6 diol as the host molecule and chemical components in extracted crude of Psoralea corylifolia L. as guest molecules, which represent different from either in sort, quantity and sites of function groups or in structural topological character, 1,1,6,6 tetraphenylhexa 2,4 diyne 1,6 diol could selectively form inclusion compound with component endowed with interactional complementarity and isolate as crystalline from the extracted crude of Psoralea corylifolia L. RESULTS The isopsoralen as guest molecule is selectively included by 1,1,6,6 tetraphenylhexa 2,4 diyne 1,6 diol in inclusion crystal and removed by acetone from the inclusion compound and total yield is 0 18%. Isopsoralen is determined by UV, IR, 1HNMR and MS and its inclusion compound is determined by means of IR, powder XRD and single crystal XRD. The isolation effect is analyzed by GC/MS. CONCLUSION The method is simple and selective for isolation isopsoralen from extracted crude of Psoralea corylifolia L.AIM To isolate the chemical components from extracted crude of Psoralea corylifolia L. METHODS Applicate the function of molecular recognition in supramolecular chemistry, use 1,1,6,6 tetraphenylhexa 2,4 diyne 1,6 diol as the host molecule and chemical components in extracted crude of Psoralea corylifolia L. as guest molecules, which represent different from either in sort, quantity and sites of function groups or in structural topological character, 1,1,6,6 tetraphenylhexa 2,4 diyne 1,6 diol could selectively form inclusion compound with component endowed with interactional complementarity and isolate as crystalline from the extracted crude of Psoralea corylifolia L. RESULTS The isopsoralen as guest molecule is selectively included by 1,1,6,6 tetraphenylhexa 2,4 diyne 1,6 diol in inclusion crystal and removed by acetone from the inclusion compound and total yield is 0 18%. Isopsoralen is determined by UV, IR, 1HNMR and MS and its inclusion compound is determined by means of IR, powder XRD and single crystal XRD. The isolation effect is analyzed by GC/MS. CONCLUSION The method is simple and selective for isolation isopsoralen from extracted crude of Psoralea corylifolia L.

关 键 词：补骨脂 异补骨脂素 包结化合物 主客体包结法 

分 类 号：R284.2[医药卫生—中药学]