DIC基础疾病患者出凝血和纤溶变化及其与预后的关系  

The relationship of disseminated intravascular coagulation(DIC) between coagulation,fibrinolysis changes and prognosis

作　　者：邓明凤[1] 陈永玲[1] 王长征[1] 黄俊[1] 廖星富[1] 袁万博[1] 

机构地区：[1]华中科技大学同济医学院附属荆州医院检验医学部,湖北荆州434020

出　　处：《中国卫生检验杂志》2013年第8期1909-1911,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨存在弥漫性微血管内凝血(DIC)基础疾病的患者出凝血、纤溶变化及其与预后的关系。方法:240名患者分为生存组和死亡组进行分析,观察二组血小板(PLT)计数,凝血酶原时间(PT),活化的部分凝血活酶时间(APTT),纤维蛋白原(Fbg),纤维蛋白(原)降解产物(FDP),硫酸鱼精蛋白副凝固(3P)试验和血浆D-二聚体(D-Dimer)等指标的变化特点。结果:DIC基础疾病患者D-Dimer阳性率最高,死亡组出凝血和纤溶阳性率均高于生存患者;对49名患者进行了动态监测和评分,死亡者DIC评分呈持续升高和/或维持在较高水平。结论:动态监测DIC基础疾病患者出凝血和纤溶指标,结合评分变化对于评估患者病情、判断预后有重要价值。Objective： To investigate the relationship agulation, fibrinolysis changes and prognosis in patients. to survival group and death group to observe the changes of disseminated intravascular coagulation （ DIC ） with co- Methods： Two hundred and forty patients were divided in- of platelet （PLT） count, prothrombin time （ PT）, activated partial thromboplastin time （AVIT）, fibrinogen （ Fbg）, fibrin （fibrinogen） degradation products （ FDP）, prota- mine paracoagulation （3P） test and D - dimer （D - Dimer）. Results： The positive rate of D - Dimer in DIC pa- tients is the highest, the coagulation and fibrinolysis in death group were significantly higher than those in the surviv- al group; It was found that the DIC score in death group was rising and / or maintained at a high level by dynamic monitoring on 49 DIC patients. Conclusion： Dynamical monitoring on coagulation and fibfinolysis of DIC patients, combined with the score, was important to evaluate the Datho^enetic condition and oroznosis.

关 键 词：DIC基础疾病 出血 凝血 纤溶 预后 

分 类 号：R554.8[医药卫生—血液循环系统疾病]