同型半胱氨酸与肾病综合征的相关性研究  

Study on the correlation between homocysteine and primary nephritic syndrome

作　　者：李炎[1] 贺志华[1] 李超伟[1] 姚振国[1] 

机构地区：[1]湖北省黄冈市中心医院,湖北黄冈438000

出　　处：《中国卫生检验杂志》2013年第8期1930-1931,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:检测同型半胱氨酸(Hcy)水平在肾病综合征(PNS)患者中的变化并探讨其在PNS诊断中的应用。方法:采用酶比色法测定117例PNS患者和123例正常对照组血清Hcy的含量,并进行统计分析。结果:血清Hcy浓度PNS患者显著高于正常对照组,而VB12水平却低于正常对照组(P<0.05)。结论:PNS患者血清Hcy浓度明显升高,而VB12水平却明显降低,高浓度的HCY是导致PNS患者发生心血管功能紊乱的危险因素。因此检测血清Hcy浓度对了解PNS患者病情具有重要意义。Objective： To investigate the changes of serum homocysteine in primary nephritic syndrome （PNS） and its application value in diagnosis of PNS. Methods： One hundred and seventeen PNS patients and 123 health individuals were chosen to measure the level of Hey using enzymatic colorimetry, then the results were analyzed with statistics. Results： The mean level of Hcy in PNS patients was significantly higher than that in normal controls （ P 〈 0.05） . But the mean level of VB12 in PNS patients was significantly lower than that in normal controls. Conclu- sion： High homocysteine level can lead to cardiovascular dysfunction in nephritic syndrome patients, so plasma Hey level detection has great value to understand the degree of PNS.

关 键 词：同型半胱氨酸 肾病综合症 相关性 

分 类 号：R692[医药卫生—泌尿科学]