慢性化脓性中耳炎患者的病原菌特点及药敏分析  

Distribution and drug sensitivity of pathogens in patients with chronic suppurative otitis media

作　　者：龙彬[1] 韩淑贞[1] 王玉杰[1] 范琴[1] 林美雄[1] 张文[1] 

机构地区：[1]武警总医院门诊部,北京100039

出　　处：《中国卫生检验杂志》2013年第8期1993-1995,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解慢性化脓性中耳炎患者的病原菌分布特点及主要致病菌对药物的敏感性,以指导临床合理用药。方法:取78例(78耳)慢性化脓性中耳炎患者的中耳分泌物,进行细菌培养和药敏试验。结果:78耳中有致病菌生长者70耳,总检出率为89.74%,其中细菌74株(构成比87.06%),真菌11株(构成比12.94%);金黄色葡萄球菌(构成比16.47%)、表皮葡萄球菌(构成比16.47%)、铜绿假单胞菌(构成比16.47%)和凝固酶阴性葡萄球菌(12.94%)为主要致病菌。三种主要致病菌:金黄色葡萄球菌、表皮葡萄球菌、铜绿假单胞菌对美罗培南敏感率较高,分别为83.33%、100%、100%;金黄色葡萄球菌、表皮葡萄球菌对莫西沙星的敏感率分别为66.67%和80%;铜绿假单胞菌对环丙沙星的敏感率为92.31%。结论:引起慢性化脓性中耳炎的病原菌主要为:金黄色葡萄球菌、表皮葡萄球菌、铜绿假单胞菌和凝固酶阴性葡萄球菌;药物敏感试验对慢性化脓性中耳炎的临床正确用药有重要指导意义。Objective： To analyze the distribution characteristics and drug sensitivity of main pathogens in chronic suppurative otitis media（CSOM） for guiding appropriate use of antibiotics in clinic. Methods： Middle ear secretion were collected from 78 CSOM patients （78 ears） to carry out bacteria culture and antimicrobial susceptibility test. Results ： Seventy strains of microbes were isolated from the 78 cases. The total detection rate was 89.74%, inclu- ding 74 strains of bacteria （87.06%） and 11 strains of fungi （ 12.94% ）. Stophylococcus aureus （ 16.47% ）, staphylococcus epidermidis （ 16.47% ）, pseudomonas aeruginosa （ 16.47% ） and coagulase negative staphylococci （ 12.94% ） were the most frequent pathogen isolates. Stophylococcus aureus, staphylococcus epidermidis and pseudo- monas aeruginosa were high sensitive to meropenem and the sensitivity rates were 83.33%, 100% and 100% re- spectively. The sensitivity rates of Stophylococcus aureus and staphylococcus epidermidis to moxifloxacin were 66. 67% and 80% respectively. The sensitivity rate of pseudomonas aeruginosa to ciprofloxacin was 92.31%. Conclu- sion： Stophylococcus aureus, staphylococcus epidermidis, pseudomonas aeruginosa and coagulase negative staphylococ- ci are the main pathogenic bacteria of CSOM, and the susceptibility test results are beneficial for choosing appropri- ate antibiotics.

关 键 词：慢性化脓性中耳炎 细菌培养 药敏试验 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]