部分抗结核分枝杆菌药物的耐药机理研究进展  

Advances in reseach on M y cobacterium tuberculosis drug resistance mechanism

作　　者：丁海榕[1] 秦川[1] 占玲俊[1] 

机构地区：[1]北京协和医学院中国医学科学院医学实验动物研究所卫生部人类疾病比较医学重点实验室国家中医药管理局人类疾病动物模型三级实验室,100021

出　　处：《中国防痨杂志》2013年第8期615-620,共6页Chinese Journal of Antituberculosis

基　　金："十二五"国家科技重大专项(2012ZX10004501)

摘　　要：结核病是危害严重的重大传染病之一,抗结核药物的应用在治疗结核病的过程中具有重要意义。然而抗结核药物治疗不当会引起耐多药和广泛耐药结核分枝杆菌的出现,导致结核病抬头。结核的耐药多与耐药基因突变有关,笔者总结了常见抗结核药物的耐药分子机制的研究进展,为耐药结核的诊断和治疗提供分子依据。Tuberculosis was one of most serious infectious diseases that were harmful to human health.Antibiotics was effective treatment against this bacterium.But the emergency of multi-and extensively drug-resistant Mycobacterium tuberculosis（Mtb） were occurred frequently when the use of antibiotics was unproper.Drug-resistant phenotype was due to mutations in drug resistant related genes,this paper will state the progress in mechanism study of drug resistant Mtb,which will guide the diagnosis and treatment of drug resistant Mtb.

关 键 词：抗结核药 抗生素类 抗结核 抗药性 细菌 

分 类 号：R446.5[医药卫生—诊断学]