精子正常形态率及其前向运动精子总数对IUI结局的影响  

Effect of the proportion of normal sperm morphology and the number of progressively motile sperm number on outcomes of intrauterine insemination pregnancy

作　　者：郑炜炜[1] 钟小英[1] 邓顺美[1] 李金芝[1] 陈爱平[1] 宋革[1] 

机构地区：[1]广东省计划生育专科医院,广东省计划生育科学技术研究所,广州510060

出　　处：《中国男科学杂志》2013年第6期30-34,共5页Chinese Journal of Andrology

基　　金：广东省科技厅重点项目广东省男性精液质量及其影响因素的研究（编号：2010B031600174）：广东省计生委重点项目男性不育患者体细胞再程序化向精原干细胞分化的研究（编号：2008001）

摘　　要：目的 探讨宫腔内人工授精（IUI）时，精子形态、前向运动精子总数及正常形态前向运动精子总数（TNPS）对IUII临床妊娠结局的影响。方法回顾性分析本中心2009年7月至2012年4月283周期IUI的病历资料，比较精子正常形态、处理后前向运动精子总数和处理后正常形态前向运动精子总数对IUI临床妊娠率的影响。结果（1）正常精子形态率分组：〈4％组、4％～10％组、10％～15％组和≥15％组的临床妊娠率分别为0％，10．00％，10．98％和21．69％，差异比较有统计学意义（P〈0．05）；（2）283周期精液处理后前向运动精子总数〈10×106组与≥10×10。组的临床妊娠率分别为11．48％和13．06％，两组比较差异无统计学意义（P〉0．05）；（3）283周期精液处理后正常形态前向运动精子总数〈0．4×10。组与≥0．4×10。组比较，临床妊娠率分别为0％和14．46％，差异有统计学意义（P〈0．05）；处理后正常形态前向运动精子总数0．4×10^61．0×10。组与1．0×10^61．5×10^6和≥1．5×10^6组比较，临床妊娠率分别为16．67％，19．05％t和13．64％，差异无统计学意义（P〉0．05）。结论（1）精子正常形态率对IuI临床妊娠率有一定影响，当正常形态≥4％可获得一定的临床妊娠率，当正常形态率≥15％可获得较高的临床妊娠率；（2）用于宫腔内人工授精的正常形态前向运动精子总数对其临床妊娠率有影响，当正常形态前向运动精子总数≥0．4×10^6。时即可获得一定的临床妊娠率。Objective To investigate the effcets ofthe proportion of normal sperm morphology and the numcer of progressively motile sperm on pregnancy rate in intrauterine insemination （IUI）. Methods Clinical data on 283 cycles from July 2009 to Apirl 2012 in our center were retrospectively analyzed. The influences of the percentage of normal sperm morphology and the number of progressively motile sperm on pregnancy rate of IUI were investigated. Results （1） The patients was classfied into four groups （〈4%, 4%-10%, 10%-15% and≥ 15%） based on the percentage of normal morphology sperm There were statistical differences in the pregnancy rate among four groups （0%, 10.00%, 10.98% and 21.69%,P〈0.05）; （2）The pregnancy rates of two groups with different number of progressively motile sperm（〈10 × 10^6and ≥ 10 ×10^6） were 11.48% and 13.06%, respectively, there was no statistical difference between these two groups （P〉0.05）; （3）The pregnancy rates were statistical difference between group with the total normal forms and progressively motile sperm number（TNPS）, less than 0.4 × 10^6 and group with more than 0.4 × 10^6, （0%vs14.46%, P〈0.05）. The pregnancy rates of groups with TNPS 0.4 × 10%1.0 ×106, 1.0 × 10%1.5 × 10^6 and≥ 1.5 ×10^6, were no statistical difference （16.67%, 19.05% and 13.64%, P〉0.05）. Conclusion （1） Normal morphology rate of sperm is important for intrauterine insemination. Above 4% normal form percentages are required for IUI. If the percentage exceeding 15%, patients will have a better pregnancy rate; （2）When the post total normal forms and progressively motile sperm number are more than 0.4 × 10^6 for intrauterine insemination, patients will get a higher pregnancy rate.

关 键 词：授精 人工 精子 妊娠率 

分 类 号：R321.33[医药卫生—人体解剖和组织胚胎学] R698.2[医药卫生—基础医学]