中药有效成分治疗线粒体病变和水通道4异常的新机制和靶点  

The Effective Ingredients of Chinese Medicine Treatment of Mitochondrial Diseases and the Water Channel of New Mechanisms and Targets of 4 Abnormal

作　　者：莫国龙[1] 戴德哉[1] 颜天华[1] 戴茵[1] 

机构地区：[1]中国药科大学药学院,江苏南京210009

出　　处：《中国医药指南》2013年第23期441-443,共3页Guide of China Medicine

基　　金：国家自然科学基金资助项目(No.81070145)

摘　　要：线粒体与水通道4(AQP4)发挥正常生理功能是维持细胞代谢平衡、氧化还原平衡等的重要保障;当它们发生异常时,细胞就易遭受氧化应激和炎性损伤,最终导致多种慢性疾病的发生。探讨与它们功能异常有关的调控蛋白及信号通路对研究中药药理与治疗作用有重要的意义。Mitochondria and aquaporin 4 are of great physiological importance in cellular metabolism and redox homeostasis; with the malfunction of which, the cells/tissues would be readily injured by oxidative stress or inflammation and culminate in some chronic diseases. Therefore, it is important to investigate the regulated proteins and signaling pathways of the malfunction of them in order to study the pharmacology and therapeutic effect of Chinese medicine.

关 键 词：线粒体 水通道4 氧化应激 中药 

分 类 号：R28[医药卫生—中药学]