胰岛素样生长因子-1在股骨头坏死治疗中的应用  

Application of insulin-like growth factor-1 in the treatment of osteonecrosis of the femoral head

作　　者：戴鹏[1] 罗军[1] 张立超[1] 陈伟才[1] 陈林攀[1] 方宁[1] 杜川[1] 

机构地区：[1]南昌大学第二附属医院康复科,南昌330006

出　　处：《中国骨质疏松杂志》2013年第8期876-880,共5页Chinese Journal of Osteoporosis

基　　金：江西省教育厅科学技术基金项目(JJ11359)

摘　　要：股骨头坏死是世界难治性疾病,目前治疗主要依靠外科手段,但效果均并不理想。胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)是一种具有促进血管生成,诱导关节软骨细胞、成骨细胞分化的生长因子。笔者通过检索查阅相关文献,简要介绍了当前对IGF-1的基础研究,重点回顾总结了IGF-1治疗股骨头坏死的理论基础,单独或联合组织工程骨、外科手段、基因整合等方式治疗股骨头坏死的进展,并对其今后的研究方向进行了展望。Osteonecrosis of the femoral head is a refractory disease worldwide. Currently, surgical treatment is the main method we can rely on, but without satisfying results. Insulin-like growth factor-1 （ IGF-1 ） is a growth factor which can promote angiogenesis, induce the differentiation of articular chondrocytes and osteoblasts. Through retrieving the related articles, this paper briefly introduces the basic research of IGF：I at present. The paper summarizes mainly on the theory basis of IGF-1 for the treatment of osteonecrosis of the femoral head and the progress on the treatment of osteonecrosis of the femoral head, including single-use or combined-use of tissue engineering bone, surgical treatment, and gene integration. This oaner also orosDects the research direction in the future.

关 键 词：股骨头坏死 IGF-1 成骨细胞 软骨细胞 

分 类 号：R34[医药卫生—基础医学]